Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 471559..472130 Replicon chromosome
Accession NZ_OV350343
Organism Halomonas sp. TD01 strain Halomonas Bluephagenesis

Toxin (Protein)


Gene name higB Uniprot ID F7SK82
Locus tag L1X57_RS02240 Protein ID WP_009722156.1
Coordinates 471852..472130 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L1X57_RS02235 Protein ID WP_009722157.1
Coordinates 471559..471852 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1X57_RS02215 (HPTD01_449) 467085..468257 + 1173 WP_009722161.1 UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase -
L1X57_RS02220 (HPTD01_450) 468335..469531 + 1197 WP_009722160.1 homoserine O-acetyltransferase -
L1X57_RS02225 (HPTD01_452) 469715..470368 - 654 WP_009722159.1 DsbA family oxidoreductase -
L1X57_RS02230 (HPTD01_453) 470480..471442 - 963 WP_009722158.1 ribonuclease Z -
L1X57_RS02235 (HPTD01_454) 471559..471852 - 294 WP_009722157.1 HigA family addiction module antitoxin Antitoxin
L1X57_RS02240 (HPTD01_455) 471852..472130 - 279 WP_009722156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L1X57_RS02245 472240..472423 - 184 Protein_438 type II toxin-antitoxin system YoeB family toxin -
L1X57_RS02250 (HPTD01_457) 472576..472857 - 282 WP_009722155.1 type II toxin-antitoxin system RelE/ParE family toxin -
L1X57_RS02255 (HPTD01_458) 472854..473126 - 273 WP_009722154.1 ribbon-helix-helix protein, CopG family -
L1X57_RS02260 (HPTD01_459) 473205..473666 - 462 WP_009722153.1 hypothetical protein -
L1X57_RS02265 (HPTD01_461) 473956..474822 - 867 WP_234667890.1 hypothetical protein -
L1X57_RS02270 (HPTD01_462) 474819..476048 - 1230 WP_009722150.1 hypothetical protein -
L1X57_RS02275 (HPTD01_463) 476045..476674 - 630 WP_009722149.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10733.27 Da        Isoelectric Point: 10.0575

>T295001 WP_009722156.1 NZ_OV350343:c472130-471852 [Halomonas sp. TD01]
MIKSFRHKGLKRFYASGSTAGIQADHAKKLRMQLAALDTAVSVEDMDIPGFRLHPLKGRDKARWSIWINGNWRMTFEFRD
GNAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10879.43 Da        Isoelectric Point: 4.7164

>AT295001 WP_009722157.1 NZ_OV350343:c471852-471559 [Halomonas sp. TD01]
MTMHNPPHPGEFIREVYLEPFGISSRQLASNLGVSPSTLSRLLKGDSGISPEMSLRLSKVLGRTPESWLSMQDMYDLWMA
RSTINLDDLQPLDFEAA

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F7SK82

Antitoxin

Source ID Structure

References