Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1569295..1569934 Replicon chromosome
Accession NZ_OV040719
Organism Haemophilus influenzae strain 3655 isolate 3655

Toxin (Protein)


Gene name higB Uniprot ID Q4QJX7
Locus tag LSO74_RS07980 Protein ID WP_005650215.1
Coordinates 1569629..1569934 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LSO74_RS07975 Protein ID WP_005650217.1
Coordinates 1569295..1569618 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSO74_RS07955 (KRLU3655_LOCUS1509) 1564914..1565087 - 174 WP_005657572.1 DUF5363 domain-containing protein -
LSO74_RS07960 (KRLU3655_LOCUS1510) 1565084..1567054 - 1971 WP_005657574.1 GNAT family N-acetyltransferase -
LSO74_RS07965 (KRLU3655_LOCUS1511) 1567059..1567400 - 342 WP_005657576.1 SirB2 family protein -
LSO74_RS07970 (KRLU3655_LOCUS1512) 1567462..1569132 - 1671 WP_005657578.1 energy-dependent translational throttle protein EttA -
LSO74_RS07975 (KRLU3655_LOCUS1513) 1569295..1569618 - 324 WP_005650217.1 HigA family addiction module antitoxin Antitoxin
LSO74_RS07980 (KRLU3655_LOCUS1514) 1569629..1569934 - 306 WP_005650215.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LSO74_RS07985 (KRLU3655_LOCUS1515) 1570259..1570879 + 621 WP_005657580.1 zinc transporter binding subunit ZevA -
LSO74_RS07990 (KRLU3655_LOCUS1516) 1570882..1571850 + 969 WP_005657582.1 zinc transporter permease subunit ZevB -
LSO74_RS08000 (KRLU3655_LOCUS1517) 1572466..1574505 + 2040 WP_005646675.1 excinuclease ABC subunit UvrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-99)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-82)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12301.93 Da        Isoelectric Point: 9.0853

>T294973 WP_005650215.1 NZ_OV040719:c1569934-1569629 [Haemophilus influenzae]
MFNLKREHFRDDYLYRFYQYGDTHSKIPSNLYKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12347.17 Da        Isoelectric Point: 6.8804

>AT294973 WP_005650217.1 NZ_OV040719:c1569618-1569295 [Haemophilus influenzae]
MMTRKPTSVGEILQEEFLEPLSLKISDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKVFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHDTSTFAM

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806EC70

Antitoxin

Source ID Structure

References