294964

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 371568..372916 Replicon chromosome
Accession NZ_OV040584
Organism Haemophilus influenzae isolate KR271

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag LSO75_RS01835 Protein ID WP_044364635.1
Coordinates 371885..372916 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A806DF96
Locus tag LSO75_RS01830 Protein ID WP_020910207.1
Coordinates 371568..371888 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSO75_RS01790 (KRLU271_LOCUS336) 366981..367259 + 279 WP_005661211.1 cell division protein FtsB -
LSO75_RS01795 (KRLU271_LOCUS337) 367259..367936 + 678 WP_011272161.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
LSO75_RS01800 (KRLU271_LOCUS338) 367933..368409 + 477 WP_006995249.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
LSO75_RS01805 (KRLU271_LOCUS339) 368716..369150 - 435 WP_005650818.1 D-aminoacyl-tRNA deacylase -
LSO75_RS01810 (KRLU271_LOCUS340) 369147..369587 - 441 WP_005667635.1 FMN-binding protein MioC -
LSO75_RS01815 (KRLU271_LOCUS341) 369686..369904 - 219 WP_005650820.1 cell division protein ZapB -
LSO75_RS01820 (KRLU271_LOCUS342) 370066..371067 + 1002 WP_011272160.1 class II fructose-bisphosphatase -
LSO75_RS01825 (KRLU271_LOCUS343) 371272..371580 + 309 WP_044364634.1 helix-turn-helix transcriptional regulator -
LSO75_RS01830 (KRLU271_LOCUS344) 371568..371888 + 321 WP_020910207.1 HipA N-terminal domain-containing protein Antitoxin
LSO75_RS01835 (KRLU271_LOCUS345) 371885..372916 + 1032 WP_044364635.1 HipA domain-containing protein Toxin
LSO75_RS01840 (KRLU271_LOCUS346) 372999..374657 - 1659 WP_044364637.1 thiol reductant ABC exporter subunit CydC -
LSO75_RS01845 (KRLU271_LOCUS347) 374650..376395 - 1746 WP_044364639.1 ABC transporter ATP-binding protein/permease -
LSO75_RS01850 (KRLU271_LOCUS348) 376444..376608 - 165 WP_044364641.1 hypothetical protein -
LSO75_RS01855 (KRLU271_LOCUS349) 376661..376825 - 165 WP_044364643.1 hypothetical protein -
LSO75_RS01860 377192..377335 + 144 Protein_351 PT domain-containing protein -
LSO75_RS01865 377275..377403 + 129 Protein_352 PT domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39847.43 Da        Isoelectric Point: 6.4335

>T294964 WP_044364635.1 NZ_OV040584:371885-372916 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIEDDHFNSINQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDKQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLVREEGNDTLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLNEPEL

Download         Length: 1032 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12438.06 Da        Isoelectric Point: 5.8850

>AT294964 WP_020910207.1 NZ_OV040584:371568-371888 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHHGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806DF96

References