Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 585321..585910 Replicon chromosome
Accession NZ_OU912926
Organism Candidatus Nitrotoga arctica strain 6680 isolate 6680

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MKZ32_RS02770 Protein ID WP_239795869.1
Coordinates 585321..585596 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag MKZ32_RS02775 Protein ID WP_239795870.1
Coordinates 585605..585910 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKZ32_RS02755 (NTG6680_0563) 581250..582314 + 1065 WP_239795866.1 glycolate oxidase subunit GlcE -
MKZ32_RS02760 (NTG6680_0564) 582320..583564 + 1245 WP_239795867.1 glycolate oxidase subunit GlcF -
MKZ32_RS02765 (NTG6680_0565) 583759..584940 + 1182 WP_239795868.1 alanine--glyoxylate aminotransferase family protein -
MKZ32_RS02770 (NTG6680_0566) 585321..585596 + 276 WP_239795869.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MKZ32_RS02775 (NTG6680_0567) 585605..585910 + 306 WP_239795870.1 HigA family addiction module antitoxin Antitoxin
MKZ32_RS15365 586032..586166 + 135 WP_275584242.1 hypothetical protein -
MKZ32_RS02780 (NTG6680_0568) 586335..586526 + 192 WP_239795871.1 hypothetical protein -
MKZ32_RS02785 (NTG6680_0569) 586553..586969 + 417 WP_239795872.1 hypothetical protein -
MKZ32_RS02790 (NTG6680_0570) 587140..587532 - 393 WP_239795873.1 hypothetical protein -
MKZ32_RS02795 (NTG6680_0571) 587590..587886 - 297 WP_239795874.1 hypothetical protein -
MKZ32_RS02800 (NTG6680_0572) 588052..588438 - 387 WP_275584311.1 hypothetical protein -
MKZ32_RS02805 (NTG6680_0573) 588382..588726 + 345 WP_239795876.1 hypothetical protein -
MKZ32_RS02810 (NTG6680_0576) 589116..589802 + 687 WP_239795877.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-91)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-62)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10580.14 Da        Isoelectric Point: 8.6126

>T294899 WP_239795869.1 NZ_OU912926:585321-585596 [Candidatus Nitrotoga arctica]
MIESFMHKGLEELFEKGKSAKVQQALVGRALRRLDAINTAKTPDVLNLPGFDFHLLQGTPKRYSVHVNRPWFITFEWEGE
NALRINLENYH

Download         Length: 276 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11107.80 Da        Isoelectric Point: 7.2781

>AT294899 WP_239795870.1 NZ_OU912926:585605-585910 [Candidatus Nitrotoga arctica]
MRKRKPTHPGAILREDVLPDLGMSVSAFARNLGVSRQTLHAILAERSGISPEMALRLGALLGNGAQLWVDMQSKYDLWQA
EDKLHDVLSSIQCLTDNQALA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References