Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 319307..319953 Replicon chromosome
Accession NZ_OU907312
Organism Unidentified bacterial endosymbiont isolate unidentified_bacterial_endosymbiont_Chironomus_riparius

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NL324_RS01615 Protein ID WP_253306058.1
Coordinates 319307..319657 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NL324_RS01620 Protein ID WP_253306059.1
Coordinates 319654..319953 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL324_RS01590 314628..314957 + 330 WP_253306054.1 thioredoxin TrxA -
NL324_RS01595 315165..315377 + 213 WP_253306055.1 hypothetical protein -
NL324_RS01600 315611..316879 + 1269 WP_253306056.1 transcription termination factor Rho -
NL324_RS01605 316907..318010 - 1104 WP_253306057.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
NL324_RS01610 318007..318954 - 948 WP_253307096.1 TDT family transporter -
NL324_RS01615 319307..319657 + 351 WP_253306058.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL324_RS01620 319654..319953 + 300 WP_253306059.1 XRE family transcriptional regulator Antitoxin
NL324_RS01625 320075..321013 - 939 WP_253307079.1 IS3 family transposase -
NL324_RS01630 320941..321240 - 300 WP_253305847.1 transposase -
NL324_RS01635 321347..322297 - 951 WP_253306060.1 methionyl-tRNA formyltransferase -
NL324_RS01640 322297..322821 - 525 WP_253306061.1 peptide deformylase -
NL324_RS01645 322969..324102 + 1134 WP_253306062.1 DNA-processing protein DprA -
NL324_RS01650 324074..324547 + 474 WP_253306063.1 DUF494 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 277675..341035 63360


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13520.47 Da        Isoelectric Point: 9.6250

>T294890 WP_253306058.1 NZ_OU907312:319307-319657 [unidentified bacterial endosymbiont]
MWTVVLTPRFYAWLHEQENGMQEKVLANLTNLETYGPKLSRPYADTVKGSRHKNMKELRVQYSGSPIRAFFAFDHERQAI
VLCAGYKSNNKRFYETMLRIADEEFTAHLSGMEGKK

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10848.67 Da        Isoelectric Point: 7.2030

>AT294890 WP_253306059.1 NZ_OU907312:319654-319953 [unidentified bacterial endosymbiont]
MKTLRDVIAAYPPESQARIKAMADEMVLETGLHLMREALQLSQKSLAESMGISQPAIAQIEQRGNDVKLATLKRYIEAMG
GKLSLTVELPEGGGRVFHI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References