29489

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2969762..2970410 Replicon chromosome
Accession NC_021251
Organism Mycobacterium tuberculosis CCDC5079

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag CFBS_RS14050 Protein ID WP_003899414.1
Coordinates 2969762..2970085 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag CFBS_RS14055 Protein ID WP_003899415.1
Coordinates 2970165..2970410 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBS_RS14020 2965085..2966083 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
CFBS_RS14025 2966097..2966561 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
CFBS_RS14030 2966549..2966800 + 252 WP_003908028.1 hypothetical protein -
CFBS_RS14035 2966971..2968410 - 1440 WP_003901443.1 phage major capsid protein -
CFBS_RS14040 2968418..2968951 - 534 WP_003899412.1 HK97 family phage prohead protease -
CFBS_RS21660 2969104..2969595 - 492 WP_003900541.1 phage terminase small subunit P27 family -
CFBS_RS14050 2969762..2970085 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
CFBS_RS14055 2970165..2970410 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
CFBS_RS14060 2970407..2971834 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
CFBS_RS14065 2971836..2972228 - 393 WP_003899417.1 DUF2742 domain-containing protein -
CFBS_RS14070 2972225..2972485 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
CFBS_RS14075 2972502..2972864 - 363 WP_003900543.1 hypothetical protein -
CFBS_RS14080 2972867..2973994 - 1128 WP_003899420.1 site-specific integrase -
CFBS_RS14085 2974139..2974366 - 228 WP_003899421.1 hypothetical protein -
CFBS_RS21665 2974363..2974752 - 390 WP_003899422.1 hypothetical protein -
CFBS_RS14090 2974658..2974930 + 273 WP_003900544.1 hypothetical protein -
CFBS_RS14095 2975029..2975262 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2965085..2973994 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T29489 WP_003899414.1 NC_021251:c2970085-2969762 [Mycobacterium tuberculosis CCDC5079]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T29489 NC_021251:c2970085-2969762 [Mycobacterium tuberculosis CCDC5079]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT29489 WP_003899415.1 NC_021251:c2970410-2970165 [Mycobacterium tuberculosis CCDC5079]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT29489 NC_021251:c2970410-2970165 [Mycobacterium tuberculosis CCDC5079]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References