Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1323762..1324373 Replicon chromosome
Accession NZ_OU745373
Organism Cardiobacterium sp. Marseille-Q4385

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag LG374_RS06460 Protein ID WP_225756922.1
Coordinates 1324191..1324373 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LG374_RS06450 Protein ID WP_225756921.1
Coordinates 1323762..1324079 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG374_RS06435 1320103..1320411 + 309 WP_225756322.1 IS630 transposase-related protein -
LG374_RS06440 1320432..1320935 + 504 WP_255594586.1 IS630 family transposase -
LG374_RS06445 1321063..1323669 - 2607 WP_225756920.1 leucine--tRNA ligase -
LG374_RS06450 1323762..1324079 - 318 WP_225756921.1 HigA family addiction module antitoxin Antitoxin
LG374_RS06455 1324094..1324153 - 60 WP_225758005.1 hypothetical protein -
LG374_RS06460 1324191..1324373 - 183 WP_225756922.1 hypothetical protein Toxin
LG374_RS06465 1324540..1325514 + 975 WP_225756923.1 thiosulfate ABC transporter substrate-binding protein CysP -
LG374_RS06470 1325584..1326555 - 972 WP_225756924.1 HemK family protein methyltransferase -
LG374_RS06475 1326622..1327416 + 795 WP_225756925.1 VacJ family lipoprotein -
LG374_RS06480 1327400..1328344 + 945 WP_225756926.1 ribosome small subunit-dependent GTPase A -
LG374_RS06485 1328341..1328607 + 267 WP_225756927.1 exodeoxyribonuclease VII small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6564.68 Da        Isoelectric Point: 10.1490

>T294884 WP_225756922.1 NZ_OU745373:c1324373-1324191 [Cardiobacterium sp. Marseille-Q4385]
MIKSFASKETKAFFAGDMVKRYQAFAAAAERKLTLLDEAKALDDLKIPMGNKLEALRGGS

Download         Length: 183 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11791.69 Da        Isoelectric Point: 6.7260

>AT294884 WP_225756921.1 NZ_OU745373:c1324079-1323762 [Cardiobacterium sp. Marseille-Q4385]
MMTKNGMRPIHPGEILREEYLAPLGLSVNALALALRVPATRMHAIVKEERSITPDTALRLARYFGTTPELWLSLQSTYDI
KIAMQSFRPEEVLPFAETQHAAETA

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References