Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3553683..3554376 Replicon chromosome
Accession NZ_OU701452
Organism Escherichia coli isolate CNR65D6

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag LWS60_RS17155 Protein ID WP_000415583.1
Coordinates 3554080..3554376 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LWS60_RS17150 Protein ID WP_000650107.1
Coordinates 3553683..3554078 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWS60_RS17140 (3549547) 3549547..3551805 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
LWS60_RS17145 (3551943) 3551943..3553550 - 1608 WP_106106577.1 ABC transporter substrate-binding protein -
LWS60_RS17150 (3553683) 3553683..3554078 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LWS60_RS17155 (3554080) 3554080..3554376 - 297 WP_000415583.1 type II toxin-antitoxin system toxin MqsR Toxin
LWS60_RS17160 (3554581) 3554581..3555063 - 483 WP_106106578.1 GyrI-like domain-containing protein -
LWS60_RS17165 (3555116) 3555116..3555508 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LWS60_RS17170 (3555660) 3555660..3556319 + 660 WP_106106579.1 quorum sensing response regulator transcription factor QseB -
LWS60_RS17175 (3556316) 3556316..3557665 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LWS60_RS17180 (3557711) 3557711..3558043 - 333 WP_000917684.1 DUF2645 family protein -
LWS60_RS17185 (3558362) 3558362..3558943 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LWS60_RS17190 (3558974) 3558974..3559288 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11216.99 Da        Isoelectric Point: 8.9070

>T294875 WP_000415583.1 NZ_OU701452:c3554376-3554080 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGLV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT294875 WP_000650107.1 NZ_OU701452:c3554078-3553683 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References