Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 737468..738161 Replicon chromosome
Accession NZ_OU701449
Organism Escherichia coli isolate CNR85I8

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag LWS57_RS03545 Protein ID WP_000415583.1
Coordinates 737468..737764 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LWS57_RS03550 Protein ID WP_000650107.1
Coordinates 737766..738161 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWS57_RS03510 (732556) 732556..732870 - 315 WP_000958598.1 putative quinol monooxygenase -
LWS57_RS03515 (732901) 732901..733482 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LWS57_RS03520 (733801) 733801..734133 + 333 WP_000917684.1 DUF2645 family protein -
LWS57_RS03525 (734179) 734179..735528 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LWS57_RS03530 (735525) 735525..736184 - 660 WP_106106579.1 quorum sensing response regulator transcription factor QseB -
LWS57_RS03535 (736336) 736336..736728 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LWS57_RS03540 (736781) 736781..737263 + 483 WP_106106578.1 GyrI-like domain-containing protein -
LWS57_RS03545 (737468) 737468..737764 + 297 WP_000415583.1 type II toxin-antitoxin system toxin MqsR Toxin
LWS57_RS03550 (737766) 737766..738161 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LWS57_RS03555 (738294) 738294..739901 + 1608 WP_106106577.1 ABC transporter substrate-binding protein -
LWS57_RS03560 (740039) 740039..742297 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11216.99 Da        Isoelectric Point: 8.9070

>T294833 WP_000415583.1 NZ_OU701449:737468-737764 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGLV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT294833 WP_000650107.1 NZ_OU701449:737766-738161 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References