Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 540072..540658 Replicon chromosome
Accession NZ_OU659204
Organism Providencia alcalifaciens strain 2019-04-29291-1-1 isolate 2019-04-29291-1-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LDO73_RS02340 Protein ID WP_282560819.1
Coordinates 540072..540362 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LDO73_RS02345 Protein ID WP_224060024.1
Coordinates 540359..540658 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO73_RS02320 (NVI2019_GHJFPKLH_00465) 535845..537401 + 1557 WP_282560818.1 NAD(P)/FAD-dependent oxidoreductase -
LDO73_RS02325 (NVI2019_GHJFPKLH_00466) 537500..538396 + 897 WP_036955277.1 transporter -
LDO73_RS02330 (NVI2019_GHJFPKLH_00467) 538448..539101 - 654 WP_224060021.1 RES family NAD+ phosphorylase -
LDO73_RS02335 (NVI2019_GHJFPKLH_00468) 539064..539804 - 741 WP_282560733.1 hypothetical protein -
LDO73_RS02340 (NVI2019_GHJFPKLH_00469) 540072..540362 + 291 WP_282560819.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO73_RS02345 (NVI2019_GHJFPKLH_00470) 540359..540658 + 300 WP_224060024.1 helix-turn-helix transcriptional regulator Antitoxin
LDO73_RS02350 (NVI2019_GHJFPKLH_00471) 540734..541741 - 1008 WP_224060025.1 AraC family transcriptional regulator -
LDO73_RS02355 (NVI2019_GHJFPKLH_00472) 542431..544656 + 2226 WP_224060026.1 indolepyruvate ferredoxin oxidoreductase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(2-85)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11039.76 Da        Isoelectric Point: 9.8549

>T294820 WP_282560819.1 NZ_OU659204:540072-540362 [Providencia alcalifaciens]
MQEKVFASLGNLEVYGPKLSRPYADTIKGSQYPNMKELRVQHMGKPIRAFFAFDPKRQAIVLCAGDKSNDKKFYSKMIRI
ADDEFSKYLASIEDKQ

Download         Length: 291 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11120.82 Da        Isoelectric Point: 7.0152

>AT294820 WP_224060024.1 NZ_OU659204:540359-540658 [Providencia alcalifaciens]
MKTLKQAIAERSLESQERIKNLTDELVLETGLQLLREELNISQKTLANNLGISQPAITQIEQRGNDIKLSTLKRYIEAMG
GKLSLTIEFPTGDGRVFHL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References