Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 52708..53300 Replicon plasmid 2
Accession NZ_OU659163
Organism Providencia alcalifaciens strain 2019-04-29292-1-3 isolate 2019-04-29292-1-3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LDO74_RS19470 Protein ID WP_036978105.1
Coordinates 53022..53300 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LDO74_RS19465 Protein ID WP_036978107.1
Coordinates 52708..53022 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO74_RS19445 47964..49105 + 1142 Protein_27 IS256 family transposase -
LDO74_RS19455 (NVI2019_OGMBKCAO_03910) 50518..51462 - 945 WP_282565831.1 conjugal transfer protein TraH -
LDO74_RS21090 (NVI2019_OGMBKCAO_03912) 51474..51626 - 153 WP_263428478.1 conjugal transfer protein TraH -
LDO74_RS19465 (NVI2019_OGMBKCAO_03913) 52708..53022 - 315 WP_036978107.1 HigA family addiction module antitoxin Antitoxin
LDO74_RS19470 (NVI2019_OGMBKCAO_03914) 53022..53300 - 279 WP_036978105.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO74_RS19485 53828..54109 - 282 WP_036978103.1 hypothetical protein -
LDO74_RS19490 (NVI2019_OGMBKCAO_03916) 54141..54674 - 534 WP_282563841.1 type-F conjugative transfer system pilin assembly protein TraF -
LDO74_RS19495 (NVI2019_OGMBKCAO_03917) 54617..54913 - 297 WP_282563840.1 hypothetical protein -
LDO74_RS19500 (NVI2019_OGMBKCAO_03918) 54883..55734 - 852 WP_282563862.1 conjugal transfer protein TraN -
LDO74_RS19505 (NVI2019_OGMBKCAO_03919) 55924..56751 - 828 WP_051420221.1 hypothetical protein -
LDO74_RS19510 (NVI2019_OGMBKCAO_03920) 56733..57368 - 636 WP_282563847.1 type-F conjugative transfer system pilin assembly protein TrbC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cdtC / cdtB / cdtB / cdtA / yopJ/yopP / stcE / exeG / prgK / prgI / sicA / spaS / spaQ / spaP / invC/sctN / invA 1..171398 171398


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10868.34 Da        Isoelectric Point: 8.4391

>T294814 WP_036978105.1 NZ_OU659163:c53300-53022 [Providencia alcalifaciens]
MIKSFKHKGLKQLFEKGITSGVPAQDAERINDRLQAIDIANDIRELDRQIYKLHPLKGDREGYWSITVRANWRITFQFIN
GDAYILNYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11382.07 Da        Isoelectric Point: 8.6057

>AT294814 WP_036978107.1 NZ_OU659163:c53022-52708 [Providencia alcalifaciens]
MRQFKISHPGEIIARDLADMGISGRRFALNIGVTPATVSRFLSGKTALTPALAIRIAAALGSTPEFWLRLQSAYDLRQLE
NQIDTSDIILYEEAPDSAKGISKH

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References