Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 146934..147526 Replicon plasmid 3
Accession NZ_OU659132
Organism Providencia alcalifaciens strain 2019-04-28370-1-5 isolate 2019-04-28370-1-5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LDO77_RS20000 Protein ID WP_036978105.1
Coordinates 146934..147212 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LDO77_RS20005 Protein ID WP_036978107.1
Coordinates 147212..147526 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO77_RS19960 (NVI2019_OHEONHNH_04009) 142866..143501 + 636 WP_282563847.1 type-F conjugative transfer system pilin assembly protein TrbC -
LDO77_RS19965 (NVI2019_OHEONHNH_04010) 143483..144310 + 828 WP_051420221.1 hypothetical protein -
LDO77_RS19970 (NVI2019_OHEONHNH_04011) 144500..145351 + 852 WP_282563862.1 conjugal transfer protein TraN -
LDO77_RS19975 (NVI2019_OHEONHNH_04012) 145321..145617 + 297 WP_282563840.1 hypothetical protein -
LDO77_RS19980 (NVI2019_OHEONHNH_04013) 145560..146093 + 534 WP_282563841.1 type-F conjugative transfer system pilin assembly protein TraF -
LDO77_RS19985 146125..146406 + 282 WP_036978103.1 hypothetical protein -
LDO77_RS20000 (NVI2019_OHEONHNH_04015) 146934..147212 + 279 WP_036978105.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO77_RS20005 (NVI2019_OHEONHNH_04016) 147212..147526 + 315 WP_036978107.1 HigA family addiction module antitoxin Antitoxin
LDO77_RS20015 (NVI2019_OHEONHNH_04019) 148608..149716 + 1109 Protein_138 conjugal transfer protein TraH -
LDO77_RS20025 151129..152270 - 1142 Protein_139 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cdtA / cdtB / cdtB / cdtC / invA / invC/sctN / spaP / spaQ / spaS / sicA / prgI / prgK / exeG / stcE / yopJ/yopP 1..171426 171426


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10868.34 Da        Isoelectric Point: 8.4391

>T294804 WP_036978105.1 NZ_OU659132:146934-147212 [Providencia alcalifaciens]
MIKSFKHKGLKQLFEKGITSGVPAQDAERINDRLQAIDIANDIRELDRQIYKLHPLKGDREGYWSITVRANWRITFQFIN
GDAYILNYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11382.07 Da        Isoelectric Point: 8.6057

>AT294804 WP_036978107.1 NZ_OU659132:147212-147526 [Providencia alcalifaciens]
MRQFKISHPGEIIARDLADMGISGRRFALNIGVTPATVSRFLSGKTALTPALAIRIAAALGSTPEFWLRLQSAYDLRQLE
NQIDTSDIILYEEAPDSAKGISKH

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References