Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 65538..66130 Replicon plasmid 2
Accession NZ_OU659119
Organism Providencia alcalifaciens strain 2019-01-3283-1-1 isolate 2019-01-3283-1-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LDO75_RS18815 Protein ID WP_036978105.1
Coordinates 65538..65816 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LDO75_RS18820 Protein ID WP_036978107.1
Coordinates 65816..66130 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO75_RS18785 (NVI2019_PEGOAJLN_03776) 61387..62022 + 636 WP_282563847.1 type-F conjugative transfer system pilin assembly protein TrbC -
LDO75_RS18790 (NVI2019_PEGOAJLN_03777) 62004..62831 + 828 WP_224063863.1 hypothetical protein -
LDO75_RS18795 (NVI2019_PEGOAJLN_03778) 63021..63872 + 852 WP_282564491.1 conjugal transfer protein TraN -
LDO75_RS18800 (NVI2019_PEGOAJLN_03779) 63842..64615 + 774 WP_224063865.1 type-F conjugative transfer system pilin assembly protein TraF -
LDO75_RS18805 (NVI2019_PEGOAJLN_03780) 64647..64928 + 282 WP_224063867.1 hypothetical protein -
LDO75_RS18815 (NVI2019_PEGOAJLN_03782) 65538..65816 + 279 WP_036978105.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO75_RS18820 (NVI2019_PEGOAJLN_03783) 65816..66130 + 315 WP_036978107.1 HigA family addiction module antitoxin Antitoxin
LDO75_RS18825 (NVI2019_PEGOAJLN_03785) 67055..68431 + 1377 Protein_70 conjugal transfer pilus assembly protein TraH -
LDO75_RS18830 (NVI2019_PEGOAJLN_03786) 68454..68675 + 222 WP_282564486.1 hypothetical protein -
LDO75_RS18835 (NVI2019_PEGOAJLN_03787) 68696..69010 + 315 WP_224063869.1 hypothetical protein -
LDO75_RS18840 (NVI2019_PEGOAJLN_03788) 69969..70454 + 486 WP_282564487.1 ProQ/FINO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - yopJ/yopP / stcE / exeG / cdtB / cdtB / cdtC / invA / invC/sctN / spaP / spaQ / spaS / sicA / prgI / prgK 1..168972 168972


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10868.34 Da        Isoelectric Point: 8.4391

>T294786 WP_036978105.1 NZ_OU659119:65538-65816 [Providencia alcalifaciens]
MIKSFKHKGLKQLFEKGITSGVPAQDAERINDRLQAIDIANDIRELDRQIYKLHPLKGDREGYWSITVRANWRITFQFIN
GDAYILNYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11382.07 Da        Isoelectric Point: 8.6057

>AT294786 WP_036978107.1 NZ_OU659119:65816-66130 [Providencia alcalifaciens]
MRQFKISHPGEIIARDLADMGISGRRFALNIGVTPATVSRFLSGKTALTPALAIRIAAALGSTPEFWLRLQSAYDLRQLE
NQIDTSDIILYEEAPDSAKGISKH

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References