Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 3897636..3898143 Replicon chromosome
Accession NZ_OU659118
Organism Providencia alcalifaciens strain 2019-01-3283-1-1 isolate 2019-01-3283-1-1

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LDO75_RS18185 Protein ID WP_006663216.1
Coordinates 3897883..3898143 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A4R3NGF7
Locus tag LDO75_RS18180 Protein ID WP_006663215.1
Coordinates 3897636..3897890 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO75_RS18160 (NVI2019_PEGOAJLN_03651) 3893193..3894341 + 1149 WP_036962553.1 polysaccharide export protein -
LDO75_RS18165 (NVI2019_PEGOAJLN_03652) 3894347..3894775 + 429 WP_224063655.1 protein tyrosine phosphatase -
LDO75_RS18170 (NVI2019_PEGOAJLN_03653) 3894803..3896884 + 2082 WP_224063656.1 polysaccharide biosynthesis tyrosine autokinase -
LDO75_RS18175 (NVI2019_PEGOAJLN_03654) 3897029..3897532 + 504 WP_006660558.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LDO75_RS18180 (NVI2019_PEGOAJLN_03655) 3897636..3897890 + 255 WP_006663215.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LDO75_RS18185 (NVI2019_PEGOAJLN_03656) 3897883..3898143 + 261 WP_006663216.1 Txe/YoeB family addiction module toxin Toxin
LDO75_RS18190 (NVI2019_PEGOAJLN_03657) 3898150..3898971 - 822 WP_006660559.1 serine O-acetyltransferase -
LDO75_RS18195 (NVI2019_PEGOAJLN_03658) 3899006..3900034 - 1029 WP_036974352.1 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase -
LDO75_RS18200 (NVI2019_PEGOAJLN_03659) 3900044..3900511 - 468 WP_006660561.1 protein-export chaperone SecB -
LDO75_RS18205 (NVI2019_PEGOAJLN_03660) 3900578..3901012 - 435 WP_224051067.1 rhodanese-like domain-containing protein -
LDO75_RS18210 (NVI2019_PEGOAJLN_03661) 3901450..3902742 + 1293 WP_006663217.1 murein hydrolase activator EnvC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10335.84 Da        Isoelectric Point: 9.4082

>T294784 WP_006663216.1 NZ_OU659118:3897883-3898143 [Providencia alcalifaciens]
MSRLLTWTDQAWEDYLYWQNQDKKTLKRINKLIEDTKRTPFSGIGKPEPLKENLAGFWSRRIDETNRLVYAIENTALVII
ACRYHY

Download         Length: 261 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9596.97 Da        Isoelectric Point: 5.8373

>AT294784 WP_006663215.1 NZ_OU659118:3897636-3897890 [Providencia alcalifaciens]
MKTISFSDARSNLKAVLDRVVDDMDTTIITRRDSEAAVVMSLEYYNSLMETIYLLRSPANAEHLNKSIEQFKAGKISERK
LINE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4R3NGF7

References