Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 146164..146756 Replicon plasmid 2
Accession NZ_OU659114
Organism Providencia alcalifaciens strain 2019-04-27799-1-2 isolate 2019-04-27799-1-2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LDO34_RS19980 Protein ID WP_036978105.1
Coordinates 146164..146442 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LDO34_RS19985 Protein ID WP_036978107.1
Coordinates 146442..146756 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO34_RS19945 (NVI2019_KOLGMIGM_04011) 142096..142731 + 636 WP_282563847.1 type-F conjugative transfer system pilin assembly protein TrbC -
LDO34_RS19950 (NVI2019_KOLGMIGM_04012) 142713..143540 + 828 WP_051420221.1 hypothetical protein -
LDO34_RS19955 (NVI2019_KOLGMIGM_04013) 143730..144581 + 852 WP_282563862.1 conjugal transfer protein TraN -
LDO34_RS19960 (NVI2019_KOLGMIGM_04014) 144551..144847 + 297 WP_282563840.1 hypothetical protein -
LDO34_RS19965 (NVI2019_KOLGMIGM_04015) 144790..145323 + 534 WP_282563841.1 type-F conjugative transfer system pilin assembly protein TraF -
LDO34_RS19970 145355..145636 + 282 WP_036978103.1 hypothetical protein -
LDO34_RS19980 (NVI2019_KOLGMIGM_04017) 146164..146442 + 279 WP_036978105.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO34_RS19985 (NVI2019_KOLGMIGM_04018) 146442..146756 + 315 WP_036978107.1 HigA family addiction module antitoxin Antitoxin
LDO34_RS19995 (NVI2019_KOLGMIGM_04021) 147838..148946 + 1109 Protein_139 conjugal transfer protein TraH -
LDO34_RS20005 150359..151500 - 1142 Protein_140 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cdtA / cdtB / cdtB / cdtC / invA / invC/sctN / spaP / spaQ / spaS / sicA / prgI / prgK / exeG / stcE / yopJ/yopP 1..170656 170656


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10868.34 Da        Isoelectric Point: 8.4391

>T294778 WP_036978105.1 NZ_OU659114:146164-146442 [Providencia alcalifaciens]
MIKSFKHKGLKQLFEKGITSGVPAQDAERINDRLQAIDIANDIRELDRQIYKLHPLKGDREGYWSITVRANWRITFQFIN
GDAYILNYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11382.07 Da        Isoelectric Point: 8.6057

>AT294778 WP_036978107.1 NZ_OU659114:146442-146756 [Providencia alcalifaciens]
MRQFKISHPGEIIARDLADMGISGRRFALNIGVTPATVSRFLSGKTALTPALAIRIAAALGSTPEFWLRLQSAYDLRQLE
NQIDTSDIILYEEAPDSAKGISKH

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References