294740

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3575175..3575677 Replicon chromosome
Accession NZ_OU342919
Organism Escherichia coli isolate UR21/11-869

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag LIX80_RS17195 Protein ID WP_000767829.1
Coordinates 3575423..3575677 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag LIX80_RS17190 Protein ID WP_001259255.1
Coordinates 3575175..3575426 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX80_RS17165 (3570352) 3570352..3571419 - 1068 WP_001548749.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
LIX80_RS17170 (3571419) 3571419..3572489 - 1071 WP_113441097.1 histidinol-phosphate transaminase -
LIX80_RS17175 (3572486) 3572486..3573790 - 1305 WP_113441096.1 histidinol dehydrogenase -
LIX80_RS17180 (3573796) 3573796..3574695 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
LIX80_RS17185 (3574841) 3574841..3574891 - 51 WP_001364200.1 his operon leader peptide -
LIX80_RS17190 (3575175) 3575175..3575426 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
LIX80_RS17195 (3575423) 3575423..3575677 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
LIX80_RS17200 (3575760) 3575760..3576584 + 825 WP_000754737.1 SDR family oxidoreductase -
LIX80_RS17205 (3576630) 3576630..3577559 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
LIX80_RS17210 (3577774) 3577774..3577836 + 63 WP_010723108.1 membrane protein YoeI -
LIX80_RS17215 (3577826) 3577826..3579184 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
LIX80_RS17220 (3579363) 3579363..3580421 + 1059 WP_000492305.1 thiosulfate utilization transporter TsuA/YeeE -
LIX80_RS17225 (3580435) 3580435..3580662 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T294740 WP_000767829.1 NZ_OU342919:3575423-3575677 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT294740 WP_001259255.1 NZ_OU342919:3575175-3575426 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References