294736

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2288325..2289124 Replicon chromosome
Accession NZ_OU342919
Organism Escherichia coli isolate UR21/11-869

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag LIX80_RS11025 Protein ID WP_000347267.1
Coordinates 2288325..2288789 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag LIX80_RS11030 Protein ID WP_001307405.1
Coordinates 2288789..2289124 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX80_RS10995 (2283326) 2283326..2283760 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
LIX80_RS11000 (2283778) 2283778..2284656 - 879 WP_123129705.1 PTS N-acetylgalactosamine transporter subunit IID -
LIX80_RS11005 (2284646) 2284646..2285425 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
LIX80_RS11010 (2285436) 2285436..2285909 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
LIX80_RS11015 (2285932) 2285932..2287212 - 1281 WP_000681947.1 tagatose-bisphosphate aldolase subunit KbaZ -
LIX80_RS11020 (2287461) 2287461..2288270 + 810 WP_000072180.1 aga operon transcriptional regulator AgaR -
LIX80_RS11025 (2288325) 2288325..2288789 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LIX80_RS11030 (2288789) 2288789..2289124 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LIX80_RS11035 (2289273) 2289273..2290844 - 1572 WP_001273741.1 galactarate dehydratase -
LIX80_RS11040 (2291219) 2291219..2292553 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
LIX80_RS11045 (2292569) 2292569..2293339 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T294736 WP_000347267.1 NZ_OU342919:c2288789-2288325 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT294736 WP_001307405.1 NZ_OU342919:c2289124-2288789 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References