Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1496001..1496603 Replicon chromosome
Accession NZ_OU342919
Organism Escherichia coli isolate UR21/11-869

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag LIX80_RS07160 Protein ID WP_000897305.1
Coordinates 1496292..1496603 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LIX80_RS07155 Protein ID WP_000356397.1
Coordinates 1496001..1496291 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX80_RS07135 (1492044) 1492044..1493221 + 1178 WP_085968792.1 IS3 family transposase -
LIX80_RS07140 (1493508) 1493508..1494488 + 981 WP_000399648.1 IS110-like element IS621 family transposase -
LIX80_RS07145 (1494717) 1494717..1494959 - 243 WP_001086388.1 protein YiiF -
LIX80_RS07150 (1495178) 1495178..1495396 - 219 WP_001295676.1 CopG family transcriptional regulator -
LIX80_RS07155 (1496001) 1496001..1496291 - 291 WP_000356397.1 NadS family protein Antitoxin
LIX80_RS07160 (1496292) 1496292..1496603 - 312 WP_000897305.1 hypothetical protein Toxin
LIX80_RS07165 (1496832) 1496832..1497740 + 909 WP_001162704.1 alpha/beta hydrolase -
LIX80_RS07170 (1497804) 1497804..1498745 - 942 WP_001343389.1 fatty acid biosynthesis protein FabY -
LIX80_RS07175 (1498790) 1498790..1499227 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
LIX80_RS07180 (1499224) 1499224..1500096 - 873 WP_000920762.1 virulence factor BrkB family protein -
LIX80_RS07185 (1500090) 1500090..1500689 - 600 WP_001295269.1 glucose-1-phosphatase -
LIX80_RS07190 (1500788) 1500788..1501573 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T294733 WP_000897305.1 NZ_OU342919:c1496603-1496292 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT294733 WP_000356397.1 NZ_OU342919:c1496291-1496001 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References