294729

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 667660..668201 Replicon chromosome
Accession NZ_OU342919
Organism Escherichia coli isolate UR21/11-869

Toxin (Protein)


Gene name yafQ Uniprot ID A7ZHY5
Locus tag LIX80_RS03255 Protein ID WP_012000916.1
Coordinates 667923..668201 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag LIX80_RS03250 Protein ID WP_000729704.1
Coordinates 667660..667920 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX80_RS03225 (663443) 663443..664228 - 786 WP_000207557.1 putative lateral flagellar export/assembly protein LafU -
LIX80_RS03230 (664200) 664200..665912 + 1713 Protein_626 flagellar biosynthesis protein FlhA -
LIX80_RS03235 (666017) 666017..666295 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
LIX80_RS03240 (666288) 666288..666644 + 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
LIX80_RS03245 (666701) 666701..667474 - 774 WP_000543899.1 C40 family peptidase -
LIX80_RS03250 (667660) 667660..667920 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
LIX80_RS03255 (667923) 667923..668201 + 279 WP_012000916.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
LIX80_RS03260 (668357) 668357..669097 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
LIX80_RS03265 (669068) 669068..669835 - 768 WP_000333380.1 class II glutamine amidotransferase -
LIX80_RS03270 (670041) 670041..670619 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T294729 WP_012000916.1 NZ_OU342919:667923-668201 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQSSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT294729 WP_000729704.1 NZ_OU342919:667660-667920 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7ZHY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6Z6

References