294664

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2468458..2468980 Replicon chromosome
Accession NZ_OU015342
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00007171 isolate AUSMDU00007171

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag KKQ83_RS12100 Protein ID WP_000221343.1
Coordinates 2468696..2468980 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag KKQ83_RS12095 Protein ID WP_000885424.1
Coordinates 2468458..2468706 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKQ83_RS12070 (2463674) 2463674..2465140 + 1467 WP_000987828.1 hypothetical protein -
KKQ83_RS12075 (2465948) 2465948..2466662 + 715 Protein_2378 helix-turn-helix domain-containing protein -
KKQ83_RS12080 (2466718) 2466718..2467626 - 909 WP_010989018.1 hypothetical protein -
KKQ83_RS12085 (2467769) 2467769..2468101 - 333 WP_000253154.1 DUF1493 family protein -
KKQ83_RS12090 (2468091) 2468091..2468306 - 216 WP_000206207.1 hypothetical protein -
KKQ83_RS12095 (2468458) 2468458..2468706 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KKQ83_RS12100 (2468696) 2468696..2468980 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KKQ83_RS12105 (2469151) 2469151..2469540 + 390 WP_000194089.1 RidA family protein -
KKQ83_RS12110 (2469592) 2469592..2470671 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
KKQ83_RS12115 (2470864) 2470864..2471352 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
KKQ83_RS12120 (2471397) 2471397..2472905 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2463677..2475762 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T294664 WP_000221343.1 NZ_OU015342:2468696-2468980 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT294664 WP_000885424.1 NZ_OU015342:2468458-2468706 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References