Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 13609..14266 | Replicon | plasmid P01 |
| Accession | NZ_OU015324 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00004549 isolate AUSMDU00004549 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | KKQ99_RS25680 | Protein ID | WP_000270043.1 |
| Coordinates | 13916..14266 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KKQ99_RS25675 | Protein ID | WP_000124640.1 |
| Coordinates | 13609..13911 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KKQ99_RS25630 (9234) | 9234..9662 | + | 429 | WP_000591074.1 | hypothetical protein | - |
| KKQ99_RS25635 (9719) | 9719..10078 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| KKQ99_RS25640 (10078) | 10078..10524 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| KKQ99_RS25645 (10521) | 10521..11039 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| KKQ99_RS25650 (11039) | 11039..11269 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| KKQ99_RS25655 (11256) | 11256..12113 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| KKQ99_RS25660 (12344) | 12344..12871 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| KKQ99_RS25665 (12929) | 12929..13201 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| KKQ99_RS25670 (13289) | 13289..13582 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| KKQ99_RS25675 (13609) | 13609..13911 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| KKQ99_RS25680 (13916) | 13916..14266 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KKQ99_RS25685 (14429) | 14429..14977 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| KKQ99_RS25690 (15151) | 15151..15318 | + | 168 | WP_015059388.1 | hypothetical protein | - |
| KKQ99_RS25695 (15318) | 15318..15512 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| KKQ99_RS25700 (15523) | 15523..15894 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| KKQ99_RS25705 (15887) | 15887..16357 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| KKQ99_RS25710 (16372) | 16372..16707 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| KKQ99_RS25715 (16804) | 16804..17292 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| KKQ99_RS25720 (17295) | 17295..17792 | + | 498 | WP_000062185.1 | hypothetical protein | - |
| KKQ99_RS25725 (18007) | 18007..18711 | - | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| KKQ99_RS25730 (18776) | 18776..18955 | - | 180 | Protein_33 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / qnrS1 / catA2 / blaCTX-M-55 / mcr-3.1 / blaTEM-1B | - | 1..123084 | 123084 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T294629 WP_000270043.1 NZ_OU015324:c14266-13916 [Salmonella enterica subsp. enterica serovar Typhimurium]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT294629 WP_000124640.1 NZ_OU015324:c13911-13609 [Salmonella enterica subsp. enterica serovar Typhimurium]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|