294625

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3618166..3618704 Replicon chromosome
Accession NZ_OU015323
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00004549 isolate AUSMDU00004549

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag KKQ99_RS18235 Protein ID WP_001526148.1
Coordinates 3618429..3618704 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag KKQ99_RS18230 Protein ID WP_000729713.1
Coordinates 3618166..3618426 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKQ99_RS18205 (3613574) 3613574..3613726 + 153 WP_001541028.1 hypothetical protein -
KKQ99_RS18210 (3613719) 3613719..3615272 + 1554 WP_000013007.1 TROVE domain-containing protein -
KKQ99_RS18215 (3615281) 3615281..3615472 + 192 Protein_3574 TROVE domain-containing protein -
KKQ99_RS18220 (3615820) 3615820..3617034 + 1215 WP_001105521.1 RNA-splicing ligase RtcB -
KKQ99_RS18225 (3617038) 3617038..3618057 + 1020 WP_000101027.1 RNA 3'-terminal phosphate cyclase -
KKQ99_RS18230 (3618166) 3618166..3618426 + 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KKQ99_RS18235 (3618429) 3618429..3618704 + 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
KKQ99_RS18240 (3618792) 3618792..3621497 - 2706 WP_000907029.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T294625 WP_001526148.1 NZ_OU015323:3618429-3618704 [Salmonella enterica subsp. enterica serovar Typhimurium]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT294625 WP_000729713.1 NZ_OU015323:3618166-3618426 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References