294621

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3049068..3049670 Replicon chromosome
Accession NZ_OU015323
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00004549 isolate AUSMDU00004549

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag KKQ99_RS15530 Protein ID WP_001159630.1
Coordinates 3049359..3049670 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KKQ99_RS15525 Protein ID WP_000362050.1
Coordinates 3049068..3049358 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKQ99_RS15510 (3046561) 3046561..3047463 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
KKQ99_RS15515 (3047460) 3047460..3048095 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
KKQ99_RS15520 (3048092) 3048092..3049021 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
KKQ99_RS15525 (3049068) 3049068..3049358 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
KKQ99_RS15530 (3049359) 3049359..3049670 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
KKQ99_RS15535 (3049888) 3049888..3050817 + 930 WP_001127703.1 alpha/beta hydrolase -
KKQ99_RS15540 (3050903) 3050903..3051214 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
KKQ99_RS15545 (3051211) 3051211..3051657 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
KKQ99_RS15550 (3051672) 3051672..3052613 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
KKQ99_RS15555 (3052658) 3052658..3053095 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
KKQ99_RS15560 (3053092) 3053092..3053964 - 873 WP_000921427.1 virulence factor BrkB family protein -
KKQ99_RS15565 (3053958) 3053958..3054557 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T294621 WP_001159630.1 NZ_OU015323:c3049670-3049359 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT294621 WP_000362050.1 NZ_OU015323:c3049358-3049068 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References