294608

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2718266..2718602 Replicon chromosome
Accession NZ_OD940440
Organism Enterococcus faecalis isolate WE0254

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag KG893_RS13445 Protein ID WP_002381035.1
Coordinates 2718266..2718409 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2718553..2718602 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KG893_RS13425 2714370..2714999 - 630 WP_002354763.1 lytic polysaccharide monooxygenase -
KG893_RS13430 2715692..2717308 + 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -
KG893_RS13435 2717638..2717781 + 144 WP_002392818.1 type I toxin-antitoxin system toxin PepG1 -
KG893_RS13440 2717900..2718040 + 141 WP_073340360.1 putative holin-like toxin -
KG893_RS13445 2718266..2718409 + 144 WP_002381035.1 putative holin-like toxin Toxin
- 2718553..2718602 + 50 - - Antitoxin
KG893_RS13450 2718604..2723295 - 4692 WP_010783624.1 WxL domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-47)


Sequences


Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T294608 WP_002381035.1 NZ_OD940440:2718266-2718409 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp


Antitoxin


Download         Length: 50 bp

>AT294608 NZ_OD940440:2718553-2718602 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2


Antitoxin

Download structure file

References