Detailed information of TA system TA294606

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2718266..2718603
• Replicon: chromosome
• Accession: NZ_OD940440
• Organism: Enterococcus faecalis isolate WE0254

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: KG893_RS13445
• Protein ID: WP_002381035.1
• Coordinates: 2718266..2718409 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2718341..2718603 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KG893_RS13425	2714370..2714999	-	630	WP_002354763.1	lytic polysaccharide monooxygenase	-
KG893_RS13430	2715692..2717308	+	1617	WP_002381036.1	phosphatase PAP2/LCP family protein	-
KG893_RS13435	2717638..2717781	+	144	WP_002392818.1	type I toxin-antitoxin system toxin PepG1	-
KG893_RS13440	2717900..2718040	+	141	WP_073340360.1	putative holin-like toxin	-
KG893_RS13445	2718266..2718409	+	144	WP_002381035.1	putative holin-like toxin	Toxin
-	2718341..2718603	-	263	-	-	Antitoxin
KG893_RS13450	2718604..2723295	-	4692	WP_010783624.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T294606 WP_002381035.1 NZ_OD940440:2718266-2718409 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 263 bp

>AT294606 NZ_OD940440:c2718603-2718341 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin