Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2718266..2718603 Replicon chromosome
Accession NZ_OD940440
Organism Enterococcus faecalis isolate WE0254

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag KG893_RS13445 Protein ID WP_002381035.1
Coordinates 2718266..2718409 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2718341..2718603 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KG893_RS13425 2714370..2714999 - 630 WP_002354763.1 lytic polysaccharide monooxygenase -
KG893_RS13430 2715692..2717308 + 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -
KG893_RS13435 2717638..2717781 + 144 WP_002392818.1 type I toxin-antitoxin system toxin PepG1 -
KG893_RS13440 2717900..2718040 + 141 WP_073340360.1 putative holin-like toxin -
KG893_RS13445 2718266..2718409 + 144 WP_002381035.1 putative holin-like toxin Toxin
- 2718341..2718603 - 263 - - Antitoxin
KG893_RS13450 2718604..2723295 - 4692 WP_010783624.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T294606 WP_002381035.1 NZ_OD940440:2718266-2718409 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 263 bp

>AT294606 NZ_OD940440:c2718603-2718341 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References