Detailed information of TA system TA294596

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2717638..2717898
• Replicon: chromosome
• Accession: NZ_OD940440
• Organism: Enterococcus faecalis isolate WE0254

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: KG893_RS13435
• Protein ID: WP_002392818.1
• Coordinates: 2717638..2717781 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2717714..2717898 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KG893_RS13415	2712760..2712975	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
KG893_RS13420	2713114..2714106	+	993	WP_002354765.1	biotin--[acetyl-CoA-carboxylase] ligase	-
KG893_RS13425	2714370..2714999	-	630	WP_002354763.1	lytic polysaccharide monooxygenase	-
KG893_RS13430	2715692..2717308	+	1617	WP_002381036.1	phosphatase PAP2/LCP family protein	-
KG893_RS13435	2717638..2717781	+	144	WP_002392818.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	2717714..2717898	-	185	-	-	Antitoxin
KG893_RS13440	2717900..2718040	+	141	WP_073340360.1	putative holin-like toxin	-
KG893_RS13445	2718266..2718409	+	144	WP_002381035.1	putative holin-like toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5344.49 Da
• Isoelectric Point: 10.6323

>T294596 WP_002392818.1 NZ_OD940440:2717638-2717781 [Enterococcus faecalis]
MNVSTKIYERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 185 bp

>AT294596 NZ_OD940440:c2717898-2717714 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin