Detailed information of TA system TA294593

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2631902..2632365
• Replicon: chromosome
• Accession: NZ_OD940440
• Organism: Enterococcus faecalis isolate WE0254

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: KG893_RS13050
• Protein ID: WP_002392696.1
• Coordinates: 2631902..2632045 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2632221..2632365 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KG893_RS13035	2627148..2627861	-	714	WP_002381063.1	trehalose operon repressor	-
KG893_RS13040	2628123..2630867	+	2745	WP_002398920.1	glycosyl hydrolase family 65 protein	-
KG893_RS13045	2630882..2631532	+	651	WP_002354875.1	beta-phosphoglucomutase	-
KG893_RS13050	2631902..2632045	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	2632221..2632365	+	145	-	-	Antitoxin
KG893_RS14920	2632453..2632578	-	126	WP_002398921.1	hypothetical protein	-
KG893_RS14925	2633119..2633394	+	276	WP_224805966.1	CPBP family intramembrane metalloprotease	-
KG893_RS13060	2633448..2634419	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
KG893_RS13065	2634594..2635031	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
KG893_RS13070	2635164..2635718	-	555	WP_002354869.1	Maf family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T294593 WP_002392696.1 NZ_OD940440:c2632045-2631902 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 145 bp

>AT294593 NZ_OD940440:2632221-2632365 [Enterococcus faecalis]
TTGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCGAT
TTTGTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAACA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin