Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2631902..2632365 Replicon chromosome
Accession NZ_OD940440
Organism Enterococcus faecalis isolate WE0254

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag KG893_RS13050 Protein ID WP_002392696.1
Coordinates 2631902..2632045 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2632221..2632365 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KG893_RS13035 2627148..2627861 - 714 WP_002381063.1 trehalose operon repressor -
KG893_RS13040 2628123..2630867 + 2745 WP_002398920.1 glycosyl hydrolase family 65 protein -
KG893_RS13045 2630882..2631532 + 651 WP_002354875.1 beta-phosphoglucomutase -
KG893_RS13050 2631902..2632045 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 2632221..2632365 + 145 - - Antitoxin
KG893_RS14920 2632453..2632578 - 126 WP_002398921.1 hypothetical protein -
KG893_RS14925 2633119..2633394 + 276 WP_224805966.1 CPBP family intramembrane metalloprotease -
KG893_RS13060 2633448..2634419 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
KG893_RS13065 2634594..2635031 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
KG893_RS13070 2635164..2635718 - 555 WP_002354869.1 Maf family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T294593 WP_002392696.1 NZ_OD940440:c2632045-2631902 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 145 bp

>AT294593 NZ_OD940440:2632221-2632365 [Enterococcus faecalis]
TTGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCGAT
TTTGTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAACA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References