Detailed information of TA system TA294577

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2808642..2808979
• Replicon: chromosome
• Accession: NZ_OD940437
• Organism: Enterococcus faecalis isolate BX8117

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: KJA90_RS13545
• Protein ID: WP_002396786.1
• Coordinates: 2808642..2808785 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2808717..2808979 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJA90_RS13525	2803858..2804073	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
KJA90_RS13530	2804212..2805204	+	993	WP_002378862.1	biotin--[acetyl-CoA-carboxylase] ligase	-
KJA90_RS13535	2805371..2806009	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
KJA90_RS13540	2806694..2808310	+	1617	WP_002378864.1	phosphatase PAP2/LCP family protein	-
KJA90_RS13545	2808642..2808785	+	144	WP_002396786.1	putative holin-like toxin	Toxin
-	2808717..2808979	-	263	-	-	Antitoxin
KJA90_RS13550	2808980..2813671	-	4692	WP_002378865.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T294577 WP_002396786.1 NZ_OD940437:2808642-2808785 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 263 bp

>AT294577 NZ_OD940437:c2808979-2808717 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin