Detailed information of TA system TA294573

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2612127..2612388
• Replicon: chromosome
• Accession: NZ_OD940437
• Organism: Enterococcus faecalis isolate BX8117

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: KJA90_RS12565
• Protein ID: WP_224561205.1
• Coordinates: 2612287..2612388 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2612127..2612338 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJA90_RS12540	2607811..2608764	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
KJA90_RS12545	2608803..2609558	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
KJA90_RS12550	2609555..2610520	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
KJA90_RS12555	2610517..2611464	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
KJA90_RS12560	2611649..2612101	+	453	WP_002378807.1	YueI family protein	-
-	2612127..2612338	+	212	-	-	Antitoxin
KJA90_RS12565	2612287..2612388	-	102	WP_224561205.1	putative holin-like toxin	Toxin
KJA90_RS12570	2612579..2614849	-	2271	WP_002378809.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
KJA90_RS12575	2615020..2615526	+	507	WP_002378810.1	cysteine hydrolase family protein	-
KJA90_RS12580	2615716..2616612	+	897	WP_002365354.1	YitT family protein	-
KJA90_RS12585	2616663..2617061	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3629.37 Da
• Isoelectric Point: 4.5869

>T294573 WP_224561205.1 NZ_OD940437:c2612388-2612287 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 212 bp

>AT294573 NZ_OD940437:2612127-2612338 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGG
TTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin