Detailed information of TA system TA294560

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2548715..2548975
• Replicon: chromosome
• Accession: NZ_OD940434
• Organism: Enterococcus faecalis isolate BX5936

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: KJA96_RS12315
• Protein ID: WP_075551663.1
• Coordinates: 2548874..2548975 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2548715..2548925 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJA96_RS12290	2544399..2545352	-	954	WP_010709946.1	siderophore ABC transporter substrate-binding protein	-
KJA96_RS12295	2545391..2546146	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
KJA96_RS12300	2546143..2547108	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
KJA96_RS12305	2547105..2548052	-	948	WP_002394759.1	iron chelate uptake ABC transporter family permease subunit	-
KJA96_RS12310	2548237..2548689	+	453	WP_002354958.1	YueI family protein	-
-	2548715..2548925	+	211	-	-	Antitoxin
KJA96_RS12315	2548874..2548975	-	102	WP_075551663.1	putative holin-like toxin	Toxin
KJA96_RS12320	2549164..2551434	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
KJA96_RS12325	2551605..2552105	+	501	WP_002365352.1	cysteine hydrolase family protein	-
KJA96_RS12330	2552804..2553700	+	897	WP_002354953.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T294560 WP_075551663.1 NZ_OD940434:c2548975-2548874 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 211 bp

>AT294560 NZ_OD940434:2548715-2548925 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCG
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGT
TATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin