Detailed information of TA system TA294553

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): fst-ratA/Fst(toxin)
• Location: 49482..49723
• Replicon: plasmid contig000003
• Accession: NZ_OD940433
• Organism: Enterococcus faecalis isolate TM6294

Toxin (Protein)

• Gene name: fst
• Uniprot ID: -
• Locus tag: KJA93_RS14065
• Protein ID: WP_002360667.1
• Coordinates: 49482..49592 (+)
• Length: 37 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	49632..49723 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJA93_RS14030 (45427)	45427..46107	+	681	WP_001015311.1	IS6-like element IS1216 family transposase	-
KJA93_RS14035 (46279)	46279..46899	+	621	WP_013438829.1	recombinase family protein	-
KJA93_RS14040 (46916)	46916..47200	+	285	WP_002394798.1	hypothetical protein	-
KJA93_RS14045 (47202)	47202..47435	+	234	WP_002394799.1	hypothetical protein	-
KJA93_RS14050 (47595)	47595..47849	-	255	WP_002394800.1	hypothetical protein	-
KJA93_RS14055 (47966)	47966..48634	-	669	WP_002403283.1	CPBP family intramembrane metalloprotease	-
KJA93_RS14060 (48670)	48670..48987	-	318	WP_002394802.1	heavy metal-binding domain-containing protein	-
KJA93_RS14065 (49482)	49482..49592	+	111	WP_002360667.1	type I toxin-antitoxin system Fst family toxin	Toxin
- (49632)	49632..49723	-	92	NuclAT_0	-	Antitoxin
- (49632)	49632..49723	-	92	NuclAT_0	-	Antitoxin
- (49632)	49632..49723	-	92	NuclAT_0	-	Antitoxin
- (49632)	49632..49723	-	92	NuclAT_0	-	Antitoxin
KJA93_RS14070 (49832)	49832..50131	+	300	WP_033598519.1	hypothetical protein	-
KJA93_RS14075 (50711)	50711..51253	-	543	WP_086321354.1	hypothetical protein	-
KJA93_RS14080 (51263)	51263..52114	-	852	WP_002362419.1	ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	fexA / optrA	prgB/asc10	1..52776	52776
	-	flank	IS/Tn	fexA / optrA	-	41123..46107	4984

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 37 a.a.
• Molecular weight: 4117.92 Da
• Isoelectric Point: 4.1672

>T294553 WP_002360667.1 NZ_OD940433:49482-49592 [Enterococcus faecalis]
VLFVKDLMSLVIAPIFVGLVLEMISRVLDEEDDNRK

Nucleotide

• Length: 111 bp

Antitoxin

Nucleotide

• Length: 92 bp

>AT294553 NZ_OD940433:c49723-49632 [Enterococcus faecalis]
TAAAAATATGTTATACTAAAGGTGCGAAACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGA
TTGCTTTTTTTT

Structures

Antitoxin