Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2707041..2707346 Replicon chromosome
Accession NZ_OD940431
Organism Enterococcus faecalis isolate TM6294

Toxin (Protein)


Gene name txpA Uniprot ID A0A6I4Y3R3
Locus tag KJA93_RS12910 Protein ID WP_033624079.1
Coordinates 2707041..2707184 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2707116..2707346 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJA93_RS12890 2702254..2702469 - 216 WP_213044572.1 zinc ribbon domain-containing protein -
KJA93_RS12895 2702608..2703600 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
KJA93_RS12900 2703767..2704405 - 639 WP_126254829.1 lytic polysaccharide monooxygenase -
KJA93_RS12905 2705092..2706708 + 1617 WP_126254830.1 phosphatase PAP2/LCP family protein -
KJA93_RS12910 2707041..2707184 + 144 WP_033624079.1 putative holin-like toxin Toxin
- 2707116..2707346 - 231 - - Antitoxin
KJA93_RS12915 2707378..2710437 - 3060 WP_161970875.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5186.29 Da        Isoelectric Point: 10.5719

>T294544 WP_033624079.1 NZ_OD940431:2707041-2707184 [Enterococcus faecalis]
MNVSAKIYERRGLLSIAEALALMISFGSFIATLIFGILKAVKEDKKK

Download         Length: 144 bp

Antitoxin


Download         Length: 231 bp

>AT294544 NZ_OD940431:c2707346-2707116 [Enterococcus faecalis]
AGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATAATAGCATTGAAAAGAGAGATATGCTGTAACAT
ACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATTTATAAAAAATAACCGTACTCGCTAAAGTAGAC
GGTTATTTTTTCTTGTCTTCTTTAACAGCTTTTAGGATTCCGAAGATTAACGTTGCGATAAAAGAGCCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I4Y3R3

Antitoxin

Download structure file

References