Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2601485..2601747 Replicon chromosome
Accession NZ_OD940431
Organism Enterococcus faecalis isolate TM6294

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag KJA93_RS12435 Protein ID WP_002392696.1
Coordinates 2601604..2601747 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2601485..2601630 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJA93_RS12420 2596850..2597563 - 714 WP_002354877.1 trehalose operon repressor -
KJA93_RS12425 2597825..2600569 + 2745 WP_126254803.1 glycosyl hydrolase family 65 protein -
KJA93_RS12430 2600584..2601234 + 651 WP_010824266.1 beta-phosphoglucomutase -
- 2601485..2601630 + 146 - - Antitoxin
KJA93_RS12435 2601604..2601747 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
KJA93_RS12440 2601979..2602950 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
KJA93_RS12445 2603125..2603562 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
KJA93_RS12450 2603695..2604249 - 555 WP_002354869.1 Maf family protein -
KJA93_RS12455 2604274..2606406 - 2133 WP_126254804.1 DNA mismatch repair endonuclease MutL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T294539 WP_002392696.1 NZ_OD940431:c2601747-2601604 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 146 bp

>AT294539 NZ_OD940431:2601485-2601630 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References