Detailed information of TA system TA294535

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-RNAII/-
• Location: 2533936..2534196
• Replicon: chromosome
• Accession: NZ_OD940431
• Organism: Enterococcus faecalis isolate TM6294

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: KJA93_RS12125
• Protein ID: WP_021164442.1
• Coordinates: 2534095..2534196 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	2533936..2534141 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJA93_RS12100	2529590..2530543	-	954	WP_126254760.1	siderophore ABC transporter substrate-binding protein	-
KJA93_RS12105	2530582..2531337	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
KJA93_RS12110	2531334..2532299	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
KJA93_RS12115	2532296..2533243	-	948	WP_002394759.1	iron chelate uptake ABC transporter family permease subunit	-
KJA93_RS12120	2533428..2533880	+	453	WP_126254759.1	YueI family protein	-
-	2533936..2534141	+	206	-	-	Antitoxin
KJA93_RS12125	2534095..2534196	-	102	WP_021164442.1	putative holin-like toxin	Toxin
KJA93_RS12130	2534387..2536657	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
KJA93_RS12135	2536828..2537334	+	507	WP_126254758.1	cysteine hydrolase family protein	-
KJA93_RS12140	2537524..2538420	+	897	WP_002365354.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3625.38 Da
• Isoelectric Point: 4.5869

>T294535 WP_021164442.1 NZ_OD940431:c2534196-2534095 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 206 bp

>AT294535 NZ_OD940431:2533936-2534141 [Enterococcus faecalis]
TTCCATTTATAATAGAATTGTGCTATTATAAAGATGAAAAAGAGAGGTATACGGGTACATACCTCTCCTTTATACCAGCG
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGT
TATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTA

Structures

Antitoxin