Detailed information of TA system TA294506

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2800906..2801168
• Replicon: chromosome
• Accession: NZ_OD940420
• Organism: Enterococcus faecalis isolate WE0438

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: KJA91_RS13420
• Protein ID: WP_002367458.1
• Coordinates: 2801025..2801168 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2800906..2801092 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJA91_RS13405 (2796317)	2796317..2797030	-	714	WP_002415630.1	trehalose operon repressor	-
KJA91_RS14685 (2797133)	2797133..2797267	-	135	WP_002415629.1	hypothetical protein	-
KJA91_RS13410 (2797291)	2797291..2800035	+	2745	WP_002415628.1	glycosyl hydrolase family 65 protein	-
KJA91_RS13415 (2800050)	2800050..2800700	+	651	WP_002415627.1	beta-phosphoglucomutase	-
- (2800769)	2800769..2800837	+	69	NuclAT_12	-	-
- (2800755)	2800755..2800839	+	85	NuclAT_5	-	-
- (2800906)	2800906..2801092	+	187	NuclAT_3	-	Antitoxin
KJA91_RS13420 (2801025)	2801025..2801168	-	144	WP_002367458.1	type I toxin-antitoxin system toxin PepG1	Toxin
- (2801269)	2801269..2801422	+	154	NuclAT_4	-	-
- (2801280)	2801280..2801424	+	145	NuclAT_11	-	-
KJA91_RS14690 (2801512)	2801512..2801637	-	126	WP_002383214.1	hypothetical protein	-
KJA91_RS13425 (2801921)	2801921..2802454	+	534	WP_002415626.1	CPBP family intramembrane metalloprotease	-
KJA91_RS13430 (2802508)	2802508..2803479	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
KJA91_RS13435 (2803654)	2803654..2804091	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
KJA91_RS13440 (2804224)	2804224..2804778	-	555	WP_002354869.1	Maf family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5311.50 Da
• Isoelectric Point: 10.8331

>T294506 WP_002367458.1 NZ_OD940420:c2801168-2801025 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 187 bp

>AT294506 NZ_OD940420:2800906-2801092 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin