Detailed information of TA system TA294501

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-RNAII/-
• Location: 2734753..2735237
• Replicon: chromosome
• Accession: NZ_OD940420
• Organism: Enterococcus faecalis isolate WE0438

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: KJA91_RS13110
• Protein ID: WP_075551663.1
• Coordinates: 2734753..2734854 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	2735028..2735237 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJA91_RS13085 (2730278)	2730278..2731231	-	954	WP_002375576.1	siderophore ABC transporter substrate-binding protein	-
KJA91_RS13090 (2731270)	2731270..2732025	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
KJA91_RS13095 (2732022)	2732022..2732987	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
KJA91_RS13100 (2732984)	2732984..2733931	-	948	WP_213044527.1	iron chelate uptake ABC transporter family permease subunit	-
KJA91_RS13105 (2734116)	2734116..2734568	+	453	WP_002354958.1	YueI family protein	-
- (2734594)	2734594..2734804	+	211	NuclAT_9	-	-
- (2734631)	2734631..2734808	+	178	NuclAT_8	-	-
KJA91_RS13110 (2734753)	2734753..2734854	-	102	WP_075551663.1	putative holin-like toxin	Toxin
- (2735028)	2735028..2735237	+	210	NuclAT_10	-	Antitoxin
- (2735062)	2735062..2735241	+	180	NuclAT_7	-	-
KJA91_RS13115 (2735186)	2735186..2735287	-	102	WP_075551663.1	putative holin-like toxin	-
KJA91_RS13120 (2735477)	2735477..2737747	-	2271	WP_002398160.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
KJA91_RS13125 (2737918)	2737918..2738418	+	501	WP_002365352.1	cysteine hydrolase family protein	-
KJA91_RS13130 (2738721)	2738721..2739617	+	897	WP_002354953.1	YitT family protein	-
KJA91_RS13135 (2739668)	2739668..2740066	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T294501 WP_075551663.1 NZ_OD940420:c2734854-2734753 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 210 bp

>AT294501 NZ_OD940420:2735028-2735237 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin