Detailed information of TA system TA294477

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2612546..2613125
• Replicon: chromosome
• Accession: NZ_LT996891
• Organism: Staphylococcus aureus isolate 24117-WT

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DYY95_RS13530
• Protein ID: WP_001025401.1
• Coordinates: 2612546..2612791 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2612760..2613125 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DYY95_RS13480	2608431..2609045	+	615	WP_000191464.1	hypothetical protein	-
DYY95_RS13485	2609042..2609188	-	147	WP_001795334.1	hypothetical protein	-
DYY95_RS13490	2609277..2609672	-	396	WP_000449655.1	hypothetical protein	-
DYY95_RS13495	2609701..2610135	-	435	WP_115657847.1	hypothetical protein	-
DYY95_RS13500	2610153..2610614	-	462	WP_000525004.1	hypothetical protein	-
DYY95_RS13505	2610627..2610941	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
DYY95_RS13510	2611093..2611329	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
DYY95_RS13515	2611343..2612119	+	777	WP_001148544.1	Rha family transcriptional regulator	-
DYY95_RS13520	2612148..2612291	+	144	WP_000939498.1	hypothetical protein	-
DYY95_RS13525	2612281..2612490	-	210	WP_000642492.1	hypothetical protein	-
DYY95_RS13530	2612546..2612791	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DYY95_RS13535	2612760..2613125	-	366	WP_001128433.1	hypothetical protein	Antitoxin
DYY95_RS13540	2613180..2613395	+	216	WP_001097552.1	hypothetical protein	-
DYY95_RS13545	2613422..2613685	+	264	WP_001124198.1	helix-turn-helix domain-containing protein	-
DYY95_RS13550	2613698..2613859	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
DYY95_RS13555	2613938..2614261	+	324	WP_000174994.1	hypothetical protein	-
DYY95_RS13560	2614276..2614638	+	363	WP_000985976.1	hypothetical protein	-
DYY95_RS13565	2614635..2615801	+	1167	WP_000762545.1	DUF2800 domain-containing protein	-
DYY95_RS13570	2615827..2616384	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2604110..2655221	51111

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294477 WP_001025401.1 NZ_LT996891:2612546-2612791 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294477 NZ_LT996891:c2613125-2612760 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin