Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1740223..1740740 Replicon chromosome
Accession NZ_LT996891
Organism Staphylococcus aureus isolate 24117-WT

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag DYY95_RS08745 Protein ID WP_000113262.1
Coordinates 1740474..1740740 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag DYY95_RS08740 Protein ID WP_000584499.1
Coordinates 1740223..1740474 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DYY95_RS08710 1735921..1736640 + 720 WP_000479576.1 amino acid ABC transporter permease -
DYY95_RS08715 1736637..1737368 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
DYY95_RS08720 1737465..1738715 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
DYY95_RS08725 1738970..1739332 + 363 WP_000819843.1 DUF4467 domain-containing protein -
DYY95_RS08730 1739351..1739950 + 600 WP_000162810.1 DsbA family protein -
DYY95_RS08735 1739957..1740058 + 102 Protein_1631 hypothetical protein -
DYY95_RS08740 1740223..1740474 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DYY95_RS08745 1740474..1740740 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
DYY95_RS08750 1741034..1742584 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
DYY95_RS08755 1742770..1743237 + 468 WP_000153344.1 SRPBCC domain-containing protein -
DYY95_RS08760 1743324..1743506 + 183 WP_000079142.1 hypothetical protein -
DYY95_RS08765 1743723..1744547 + 825 WP_000572040.1 formate/nitrite transporter family protein -
DYY95_RS08770 1744781..1745317 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T294469 WP_000113262.1 NZ_LT996891:1740474-1740740 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT294469 WP_000584499.1 NZ_LT996891:1740223-1740474 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References