Detailed information of TA system TA294464

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2612544..2613123
• Replicon: chromosome
• Accession: NZ_LT996890
• Organism: Staphylococcus aureus isolate 24117-SCV

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DYY94_RS13530
• Protein ID: WP_001025401.1
• Coordinates: 2612544..2612789 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2612758..2613123 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DYY94_RS13480	2608429..2609043	+	615	WP_000191464.1	hypothetical protein	-
DYY94_RS13485	2609040..2609186	-	147	WP_001795334.1	hypothetical protein	-
DYY94_RS13490	2609275..2609670	-	396	WP_000449655.1	hypothetical protein	-
DYY94_RS13495	2609699..2610133	-	435	WP_115657847.1	hypothetical protein	-
DYY94_RS13500	2610151..2610612	-	462	WP_000525004.1	hypothetical protein	-
DYY94_RS13505	2610625..2610939	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
DYY94_RS13510	2611091..2611327	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
DYY94_RS13515	2611341..2612117	+	777	WP_001148544.1	Rha family transcriptional regulator	-
DYY94_RS13520	2612146..2612289	+	144	WP_000939498.1	hypothetical protein	-
DYY94_RS13525	2612279..2612488	-	210	WP_000642492.1	hypothetical protein	-
DYY94_RS13530	2612544..2612789	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DYY94_RS13535	2612758..2613123	-	366	WP_001128433.1	hypothetical protein	Antitoxin
DYY94_RS13540	2613178..2613393	+	216	WP_001097552.1	hypothetical protein	-
DYY94_RS13545	2613420..2613683	+	264	WP_001124198.1	helix-turn-helix domain-containing protein	-
DYY94_RS13550	2613696..2613857	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
DYY94_RS13555	2613936..2614259	+	324	WP_000174994.1	hypothetical protein	-
DYY94_RS13560	2614274..2614636	+	363	WP_000985976.1	hypothetical protein	-
DYY94_RS13565	2614633..2615799	+	1167	WP_000762545.1	DUF2800 domain-containing protein	-
DYY94_RS13570	2615825..2616382	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2604108..2655219	51111

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294464 WP_001025401.1 NZ_LT996890:2612544-2612789 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294464 NZ_LT996890:c2613123-2612758 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin