Detailed information of TA system TA294451

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2612543..2613122
• Replicon: chromosome
• Accession: NZ_LT996889
• Organism: Staphylococcus aureus isolate 24117-REV

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DYY93_RS13530
• Protein ID: WP_001025401.1
• Coordinates: 2612543..2612788 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2612757..2613122 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DYY93_RS13480	2608428..2609042	+	615	WP_000191464.1	hypothetical protein	-
DYY93_RS13485	2609039..2609185	-	147	WP_001795334.1	hypothetical protein	-
DYY93_RS13490	2609274..2609669	-	396	WP_000449655.1	hypothetical protein	-
DYY93_RS13495	2609698..2610132	-	435	WP_115657847.1	hypothetical protein	-
DYY93_RS13500	2610150..2610611	-	462	WP_000525004.1	hypothetical protein	-
DYY93_RS13505	2610624..2610938	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
DYY93_RS13510	2611090..2611326	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
DYY93_RS13515	2611340..2612116	+	777	WP_001148544.1	Rha family transcriptional regulator	-
DYY93_RS13520	2612145..2612288	+	144	WP_000939498.1	hypothetical protein	-
DYY93_RS13525	2612278..2612487	-	210	WP_000642492.1	hypothetical protein	-
DYY93_RS13530	2612543..2612788	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DYY93_RS13535	2612757..2613122	-	366	WP_001128433.1	hypothetical protein	Antitoxin
DYY93_RS13540	2613177..2613392	+	216	WP_001097552.1	hypothetical protein	-
DYY93_RS13545	2613419..2613682	+	264	WP_001124198.1	helix-turn-helix domain-containing protein	-
DYY93_RS13550	2613695..2613856	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
DYY93_RS13555	2613935..2614258	+	324	WP_000174994.1	hypothetical protein	-
DYY93_RS13560	2614273..2614635	+	363	WP_000985976.1	hypothetical protein	-
DYY93_RS13565	2614632..2615798	+	1167	WP_000762545.1	DUF2800 domain-containing protein	-
DYY93_RS13570	2615824..2616381	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2604107..2655218	51111

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294451 WP_001025401.1 NZ_LT996889:2612543-2612788 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294451 NZ_LT996889:c2613122-2612757 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin