Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4625284..4625886 Replicon chromosome
Accession NZ_LT992502
Organism Enterobacter bugandensis isolate EB-247

Toxin (Protein)


Gene name higB Uniprot ID A0A167J774
Locus tag DG357_RS22445 Protein ID WP_047366784.1
Coordinates 4625575..4625886 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A167J796
Locus tag DG357_RS22440 Protein ID WP_047366785.1
Coordinates 4625284..4625574 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG357_RS22425 4622782..4623684 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
DG357_RS22430 4623681..4624316 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
DG357_RS22435 4624313..4625242 + 930 WP_063437456.1 formate dehydrogenase accessory protein FdhE -
DG357_RS22440 4625284..4625574 - 291 WP_047366785.1 helix-turn-helix domain-containing protein Antitoxin
DG357_RS22445 4625575..4625886 - 312 WP_047366784.1 hypothetical protein Toxin
DG357_RS22450 4626035..4626976 - 942 WP_047366783.1 fatty acid biosynthesis protein FabY -
DG357_RS22455 4627021..4627458 - 438 WP_008501836.1 D-tyrosyl-tRNA(Tyr) deacylase -
DG357_RS22460 4627455..4628336 - 882 WP_045260235.1 virulence factor BrkB family protein -
DG357_RS22465 4628330..4628929 - 600 WP_045260234.1 glucose-1-phosphatase -
DG357_RS22470 4629017..4629487 - 471 WP_028014878.1 hypothetical protein -
DG357_RS22475 4629484..4630227 - 744 WP_048959977.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12135.13 Da        Isoelectric Point: 8.8415

>T294432 WP_047366784.1 NZ_LT992502:c4625886-4625575 [Enterobacter bugandensis]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPEYGDVIQNTGGLRKIRWLAGGKGKRGGVRVIYFYRTCEFEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10674.22 Da        Isoelectric Point: 10.5888

>AT294432 WP_047366785.1 NZ_LT992502:c4625574-4625284 [Enterobacter bugandensis]
MDKALFERLTQSVGQMNEIAEGQREPSRIFQIDAMKIKEIRQASGLSQSKFATLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A167J774

Antitoxin

Source ID Structure
AlphaFold DB A0A167J796

References