Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 4457454..4458108 Replicon chromosome
Accession NC_021237
Organism Pseudomonas protegens CHA0

Toxin (Protein)


Gene name higB Uniprot ID A0A2C9EQ14
Locus tag PFLCHA0_RS19870 Protein ID WP_015636300.1
Coordinates 4457454..4457804 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID Q4K9S2
Locus tag PFLCHA0_RS19875 Protein ID WP_011062198.1
Coordinates 4457791..4458108 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFLCHA0_RS19860 4454213..4455745 + 1533 WP_015636298.1 NADH-quinone oxidoreductase subunit M -
PFLCHA0_RS19865 4455753..4457216 + 1464 WP_015636299.1 NADH-quinone oxidoreductase subunit NuoN -
PFLCHA0_RS19870 4457454..4457804 + 351 WP_015636300.1 hypothetical protein Toxin
PFLCHA0_RS19875 4457791..4458108 + 318 WP_011062198.1 transcriptional regulator Antitoxin
PFLCHA0_RS19880 4458181..4459563 - 1383 WP_015636301.1 cysteine--tRNA ligase -
PFLCHA0_RS19885 4459582..4461282 - 1701 WP_015636302.1 glutamine--tRNA ligase/YqeY domain fusion protein -
PFLCHA0_RS19890 4461553..4462056 + 504 WP_011062201.1 peptidyl-prolyl cis-trans isomerase -
PFLCHA0_RS19895 4462053..4462805 + 753 WP_015636303.1 UDP-2,3-diacylglucosamine diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(48-101)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 14008.14 Da        Isoelectric Point: 8.9805

>T29441 WP_015636300.1 NC_021237:4457454-4457804 [Pseudomonas protegens CHA0]
MNALFIELPAFARYRKGFLDDELFCELQIELLRHPHAGVLIQGTGGLRKMRFIDERRNKGRRGGLRVIYYWWSEGAQFWL
FTLFDKEQMDDLLPQQRQQLKQLLEREIEARRHDQT

Download         Length: 351 bp

>T29441 NC_021237:4457454-4457804 [Pseudomonas protegens CHA0]
ATGAATGCTCTGTTTATTGAACTACCGGCATTTGCGCGATACCGAAAAGGCTTCCTTGACGACGAGTTGTTCTGCGAACT
GCAGATCGAGTTGCTGCGCCACCCGCACGCGGGTGTTCTGATTCAGGGCACTGGCGGCTTGCGCAAGATGCGTTTCATCG
ATGAGCGACGCAACAAGGGCAGGCGTGGCGGGCTGAGGGTGATTTATTACTGGTGGTCCGAAGGAGCACAGTTCTGGCTC
TTCACCCTGTTCGACAAGGAGCAGATGGACGACCTGCTACCGCAGCAGCGACAACAGCTCAAACAACTGCTGGAACGTGA
AATCGAGGCCAGAAGACATGACCAAACGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12064.95 Da        Isoelectric Point: 10.4439

>AT29441 WP_011062198.1 NC_021237:4457791-4458108 [Pseudomonas protegens CHA0]
MTKRDIFSELVEGIDALTQERQGKITLRSHKVKLEKLPPITAAEVMNIRQQLNLSRSVFAMYLRTNTRTLENWEQGRAIP
NAQATTLIRLVERYPDTVERLASLA

Download         Length: 318 bp

>AT29441 NC_021237:4457791-4458108 [Pseudomonas protegens CHA0]
ATGACCAAACGTGACATCTTTTCCGAACTGGTAGAAGGCATCGACGCCCTCACCCAGGAACGCCAGGGCAAGATCACCCT
GCGCAGCCATAAAGTGAAGCTCGAAAAGCTGCCGCCCATCACCGCCGCCGAGGTGATGAACATCCGCCAGCAACTCAACC
TCTCGCGCTCGGTATTCGCCATGTACCTGCGCACCAACACCCGCACCCTGGAGAACTGGGAACAGGGCCGCGCCATACCC
AACGCCCAGGCCACGACCTTGATACGCCTGGTGGAACGCTACCCCGATACAGTGGAGCGCCTCGCCTCGCTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9EQ14

Antitoxin

Source ID Structure
AlphaFold DB A0A2C9EPZ9

References