294405

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2401852..2402450 Replicon chromosome
Accession NZ_LT992492
Organism Vibrio cholerae strain 4295STDY6534248

Toxin (Protein)


Gene name higB Uniprot ID Q8KQX9
Locus tag DG169_RS11265 Protein ID WP_000118545.1
Coordinates 2401852..2402175 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DG169_RS11270 Protein ID WP_000058216.1
Coordinates 2402172..2402450 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG169_RS11235 2397565..2397951 - 387 WP_000180225.1 hypothetical protein -
DG169_RS11240 2397948..2398520 - 573 WP_139057167.1 type IV conjugative transfer system lipoprotein TraV -
DG169_RS11245 2398595..2399884 - 1290 WP_001883765.1 TraB/VirB10 family protein -
DG169_RS11250 2399887..2400783 - 897 WP_032467354.1 type-F conjugative transfer system secretin TraK -
DG169_RS11255 2400767..2401393 - 627 WP_000667169.1 hypothetical protein -
DG169_RS11260 2401390..2401671 - 282 WP_000433889.1 type IV conjugative transfer system protein TraL -
DG169_RS11265 2401852..2402175 + 324 WP_000118545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DG169_RS11270 2402172..2402450 + 279 WP_000058216.1 helix-turn-helix domain-containing protein Antitoxin
DG169_RS11275 2402476..2403111 - 636 WP_000033753.1 DUF4400 domain-containing protein -
DG169_RS11280 2403098..2403658 - 561 WP_000546510.1 hypothetical protein -
DG169_RS11285 2403668..2405488 - 1821 WP_000661887.1 conjugative transfer system coupling protein TraD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2310264..2443147 132883


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-81)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12267.26 Da        Isoelectric Point: 9.4705

>T294405 WP_000118545.1 NZ_LT992492:2401852-2402175 [Vibrio cholerae]
MSWKIDFYDGVEDQILDMPPKIQARMIKLLELMEKHGANLGPPHTESMGDGLFEIRAKAQEGIGRGLFCYLKGNHIYVLH
AFVKKSQKTPKNELNLARDRQKEVQKS

Download         Length: 324 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10517.07 Da        Isoelectric Point: 9.9393

>AT294405 WP_000058216.1 NZ_LT992492:2402172-2402450 [Vibrio cholerae]
MSLQKLKQRALANAEVKNEYDKLESEFSFIDQLLTMRTKAGLTQEQVAERMHTQKSNVSRLEKGNANPSWSTLLKYAHAC
GFELTLKPQKMS

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1L383

Antitoxin

Source ID Structure

References