29437

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1618370..1618884 Replicon chromosome
Accession NC_021235
Organism Lactobacillus fermentum F-6

Toxin (Protein)


Gene name yoeB Uniprot ID A0A806J0V5
Locus tag LBFF_RS08040 Protein ID WP_015639360.1
Coordinates 1618370..1618633 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A806IV92
Locus tag LBFF_RS08045 Protein ID WP_015639361.1
Coordinates 1618630..1618884 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LBFF_RS08020 1613646..1614896 - 1251 WP_041813976.1 transposase -
LBFF_RS08025 1614970..1615425 + 456 WP_015639357.1 IS200/IS605 family transposase -
LBFF_RS08030 1615632..1616318 + 687 WP_015639358.1 hypothetical protein -
LBFF_RS08035 1616840..1617961 + 1122 WP_015639359.1 PTS sugar transporter subunit IIC -
LBFF_RS08040 1618370..1618633 - 264 WP_015639360.1 Txe/YoeB family addiction module toxin Toxin
LBFF_RS08045 1618630..1618884 - 255 WP_015639361.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LBFF_RS08050 1619217..1620437 - 1221 WP_015639362.1 IS256 family transposase -
LBFF_RS08055 1620571..1621461 + 891 Protein_1567 IS30 family transposase -
LBFF_RS08060 1621893..1623263 - 1371 WP_015639364.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1613646..1630592 16946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-78)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-55)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10250.93 Da        Isoelectric Point: 10.3349

>T29437 WP_015639360.1 NC_021235:c1618633-1618370 [Lactobacillus fermentum F-6]
MSYAIKLKRSANKELKKIKGSYLEKSFLQIIEQLRKDPLAPNQGFEKLVPPIKGFYSRRINIQHRLVYKVDQDTQTVIIY
SAWSHDE

Download         Length: 264 bp

>T29437 NC_021235:c1618633-1618370 [Lactobacillus fermentum F-6]
ATGAGTTACGCGATCAAACTCAAGCGGAGCGCTAATAAAGAACTCAAGAAAATTAAGGGGTCATATTTAGAAAAGAGCTT
CTTGCAAATAATTGAGCAGCTCCGTAAAGACCCCTTGGCACCCAACCAAGGCTTTGAAAAATTGGTACCGCCAATTAAGG
GCTTTTACTCCCGGCGGATTAACATTCAGCACCGACTCGTCTATAAGGTTGATCAAGACACGCAAACTGTGATCATCTAT
TCTGCGTGGTCACATGACGAATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9745.08 Da        Isoelectric Point: 4.5517

>AT29437 WP_015639361.1 NC_021235:c1618884-1618630 [Lactobacillus fermentum F-6]
MDKIVTPTQARKDLFKIIKRINENNEPVVIKPTKADEKSVVVIGEDDWKAIQETLFLVNHGVDKQIKERENEPLDDFDDV
WGQL

Download         Length: 255 bp

>AT29437 NC_021235:c1618884-1618630 [Lactobacillus fermentum F-6]
ATGGACAAAATTGTAACCCCAACGCAAGCACGGAAAGATTTATTCAAAATAATCAAAAGGATCAATGAAAATAATGAGCC
GGTTGTGATTAAGCCGACCAAGGCGGATGAAAAGAGCGTTGTCGTCATTGGTGAAGATGACTGGAAAGCAATCCAAGAAA
CGTTATTTTTGGTTAATCACGGTGTTGATAAGCAAATTAAAGAACGGGAAAACGAGCCGCTCGACGACTTTGATGATGTT
TGGGGTCAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806J0V5

Antitoxin

Source ID Structure
AlphaFold DB A0A806IV92

References