Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2401853..2402451 Replicon chromosome
Accession NZ_LT992488
Organism Vibrio cholerae strain 4295STDY6534232

Toxin (Protein)


Gene name higB Uniprot ID Q8KQX9
Locus tag DG176_RS11265 Protein ID WP_000118545.1
Coordinates 2401853..2402176 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DG176_RS11270 Protein ID WP_000058216.1
Coordinates 2402173..2402451 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG176_RS11235 2397566..2397952 - 387 WP_000180225.1 hypothetical protein -
DG176_RS11240 2397949..2398521 - 573 WP_139057167.1 type IV conjugative transfer system lipoprotein TraV -
DG176_RS11245 2398596..2399885 - 1290 WP_001883765.1 TraB/VirB10 family protein -
DG176_RS11250 2399888..2400784 - 897 WP_032467354.1 type-F conjugative transfer system secretin TraK -
DG176_RS11255 2400768..2401394 - 627 WP_000667169.1 hypothetical protein -
DG176_RS11260 2401391..2401672 - 282 WP_000433889.1 type IV conjugative transfer system protein TraL -
DG176_RS11265 2401853..2402176 + 324 WP_000118545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DG176_RS11270 2402173..2402451 + 279 WP_000058216.1 helix-turn-helix domain-containing protein Antitoxin
DG176_RS11275 2402477..2403112 - 636 WP_000033753.1 DUF4400 domain-containing protein -
DG176_RS11280 2403099..2403659 - 561 WP_000546510.1 hypothetical protein -
DG176_RS11285 2403669..2405489 - 1821 WP_000661887.1 conjugative transfer system coupling protein TraD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2310265..2443148 132883


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-81)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12267.26 Da        Isoelectric Point: 9.4705

>T294367 WP_000118545.1 NZ_LT992488:2401853-2402176 [Vibrio cholerae]
MSWKIDFYDGVEDQILDMPPKIQARMIKLLELMEKHGANLGPPHTESMGDGLFEIRAKAQEGIGRGLFCYLKGNHIYVLH
AFVKKSQKTPKNELNLARDRQKEVQKS

Download         Length: 324 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10517.07 Da        Isoelectric Point: 9.9393

>AT294367 WP_000058216.1 NZ_LT992488:2402173-2402451 [Vibrio cholerae]
MSLQKLKQRALANAEVKNEYDKLESEFSFIDQLLTMRTKAGLTQEQVAERMHTQKSNVSRLEKGNANPSWSTLLKYAHAC
GFELTLKPQKMS

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1L383

Antitoxin

Source ID Structure

References