Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 323996..324584 Replicon chromosome
Accession NC_021218
Organism Helicobacter pylori UM066

Toxin (Protein)


Gene name TfiT Uniprot ID K2LF18
Locus tag K751_RS01560 Protein ID WP_000921926.1
Coordinates 324303..324584 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID R4QM59
Locus tag K751_RS01555 Protein ID WP_015643204.1
Coordinates 323996..324310 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K751_RS01535 319519..320175 + 657 WP_015643207.1 ParA family protein -
K751_RS01540 320257..320541 + 285 WP_000394639.1 hypothetical protein -
K751_RS01545 320573..321757 + 1185 WP_015643206.1 hypothetical protein -
K751_RS01550 321782..323692 - 1911 WP_015643205.1 relaxase/mobilization nuclease domain-containing protein -
K751_RS01555 323996..324310 + 315 WP_015643204.1 hypothetical protein Antitoxin
K751_RS01560 324303..324584 + 282 WP_000921926.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
K751_RS01565 324908..326635 - 1728 WP_015643203.1 type IV secretory system conjugative DNA transfer family protein -
K751_RS01570 326636..327193 - 558 WP_015643202.1 hypothetical protein -
K751_RS01575 327194..327484 - 291 WP_000159825.1 hypothetical protein -
K751_RS01580 327481..327936 - 456 WP_015643201.1 hypothetical protein -
K751_RS01585 327933..328874 - 942 WP_015643200.1 CpaF/VirB11 family protein -
K751_RS01590 328874..329173 - 300 WP_015643199.1 hypothetical protein -
K751_RS01595 329170..329433 - 264 WP_015643198.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10932.89 Da        Isoelectric Point: 9.8257

>T29435 WP_000921926.1 NC_021218:324303-324584 [Helicobacter pylori UM066]
MLKVRTKKDFLKDFNKHILSGRIKESDVTSIVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T29435 NC_021218:324303-324584 [Helicobacter pylori UM066]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTAAAGAAAGCGA
TGTTACAAGCATTGTTGATTGCCTCAAAGAGCAAAAACCACTCCAACAAAAATATTGCGACCATGCCTTGAGTGGCAATC
TTAAAGGGCTGAGAGAGTGTCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGTGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12181.61 Da        Isoelectric Point: 5.2068

>AT29435 WP_015643204.1 NC_021218:323996-324310 [Helicobacter pylori UM066]
MSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
YDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT29435 NC_021218:323996-324310 [Helicobacter pylori UM066]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAGAAGCAACTGCACAATTTCTTAAACGCCATTGAAAAGCAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTGGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATCGCCTCAAAAGATGACCCAGAA
TACGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2LF18

Antitoxin

Source ID Structure
AlphaFold DB R4QM59

References