Detailed information of TA system TA294343

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2483439..2483746
• Replicon: chromosome
• Accession: NZ_LT992477
• Organism: Staphylococcus aureus isolate 22_LA_562

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DXE38_RS12680
• Protein ID: WP_011447039.1
• Coordinates: 2483439..2483615 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2483607..2483746 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE38_RS12660	2478674..2482459	+	3786	WP_000582165.1	hypothetical protein	-
DXE38_RS12665	2482449..2482601	+	153	WP_001153681.1	hypothetical protein	-
DXE38_RS12670	2482648..2482935	+	288	WP_001040261.1	hypothetical protein	-
DXE38_RS12675	2482993..2483289	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
DXE38_RS12680	2483439..2483615	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	2483607..2483746	-	140	NuclAT_0	-	Antitoxin
-	2483607..2483746	-	140	NuclAT_0	-	Antitoxin
-	2483607..2483746	-	140	NuclAT_0	-	Antitoxin
-	2483607..2483746	-	140	NuclAT_0	-	Antitoxin
DXE38_RS12685	2483668..2483775	-	108	WP_001791821.1	hypothetical protein	-
DXE38_RS12690	2483827..2484081	+	255	WP_000611512.1	phage holin	-
DXE38_RS12695	2484093..2484848	+	756	WP_064131634.1	CHAP domain-containing protein	-
DXE38_RS12700	2485039..2485530	+	492	WP_000919350.1	staphylokinase	-
DXE38_RS12705	2486189..2486539	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
DXE38_RS12710	2486592..2486852	-	261	WP_001791826.1	hypothetical protein	-
DXE38_RS12720	2487163..2487342	-	180	WP_000669789.1	hypothetical protein	-
DXE38_RS12725	2487664..2487911	-	248	Protein_2377	sphingomyelin phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / scn	2436628..2486539	49911

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T294343 WP_011447039.1 NZ_LT992477:2483439-2483615 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294343 NZ_LT992477:c2483746-2483607 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin