Detailed information of TA system TA294336

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2310988..2311251
• Replicon: chromosome
• Accession: NZ_LT992477
• Organism: Staphylococcus aureus isolate 22_LA_562

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: DXE38_RS11685
• Protein ID: WP_001802298.1
• Coordinates: 2310988..2311092 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2311087..2311251 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE38_RS11650	2306887..2307495	+	609	WP_000101714.1	TIR domain-containing protein	-
DXE38_RS11655	2307785..2308567	+	783	WP_000908191.1	ABC transporter ATP-binding protein	-
DXE38_RS11660	2308635..2309492	+	858	WP_000370942.1	Cof-type HAD-IIB family hydrolase	-
DXE38_RS11665	2309622..2309714	-	93	WP_000220902.1	hypothetical protein	-
DXE38_RS11670	2310150..2310308	-	159	WP_001792784.1	hypothetical protein	-
DXE38_RS11685	2310988..2311092	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2311087..2311251	-	165	-	-	Antitoxin
DXE38_RS11690	2311590..2312681	-	1092	WP_000495673.1	hypothetical protein	-
DXE38_RS11695	2312947..2313927	-	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
DXE38_RS11700	2313929..2314249	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
DXE38_RS11705	2314401..2315066	+	666	WP_001024099.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T294336 WP_001802298.1 NZ_LT992477:2310988-2311092 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

Antitoxin

Nucleotide

• Length: 165 bp

>AT294336 NZ_LT992477:c2311251-2311087 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin