Detailed information of TA system TA294327

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2734557..2735136
• Replicon: chromosome
• Accession: NZ_LT992476
• Organism: Staphylococcus aureus isolate 21_LA_436

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DXE57_RS14290
• Protein ID: WP_001025401.1
• Coordinates: 2734891..2735136 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2734557..2734922 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE57_RS14250	2731300..2731857	-	558	WP_000645042.1	DUF2815 family protein	-
DXE57_RS14255	2731883..2733049	-	1167	WP_000762534.1	DUF2800 domain-containing protein	-
DXE57_RS14260	2733046..2733408	-	363	WP_000985986.1	hypothetical protein	-
DXE57_RS14265	2733423..2733746	-	324	WP_000174994.1	hypothetical protein	-
DXE57_RS14270	2733825..2733986	-	162	WP_031882238.1	DUF1270 family protein	-
DXE57_RS14275	2733999..2734262	-	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
DXE57_RS14280	2734287..2734502	-	216	WP_001036302.1	hypothetical protein	-
DXE57_RS14285	2734557..2734922	+	366	WP_001128433.1	hypothetical protein	Antitoxin
DXE57_RS14290	2734891..2735136	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DXE57_RS14295	2735192..2735401	+	210	WP_000642492.1	hypothetical protein	-
DXE57_RS14300	2735391..2735534	-	144	WP_000939498.1	hypothetical protein	-
DXE57_RS14305	2735563..2736339	-	777	WP_001148544.1	Rha family transcriptional regulator	-
DXE57_RS14310	2736353..2736589	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
DXE57_RS14315	2736742..2737056	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
DXE57_RS14320	2737069..2737530	+	462	WP_000525004.1	hypothetical protein	-
DXE57_RS14325	2737548..2738132	+	585	WP_079219805.1	hypothetical protein	-
DXE57_RS14330	2738361..2738507	+	147	WP_001013104.1	hypothetical protein	-
DXE57_RS14335	2738504..2739118	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2695350..2740449	45099

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294327 WP_001025401.1 NZ_LT992476:c2735136-2734891 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294327 NZ_LT992476:2734557-2734922 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin