Detailed information of TA system TA294323

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1999506..1999703
• Replicon: chromosome
• Accession: NZ_LT992476
• Organism: Staphylococcus aureus isolate 21_LA_436

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: DXE57_RS10270
• Protein ID: WP_000623369.1
• Coordinates: 1999596..1999703 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1999506..1999543 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE57_RS10235	1994607..1994963	+	357	WP_000766009.1	DoxX family protein	-
DXE57_RS10240	1995052..1995240	-	189	WP_157958947.1	poly(glycerol-phosphate) alpha-glucosyltransferase	-
DXE57_RS10245	1995330..1995620	+	291	WP_001796515.1	hypothetical protein	-
DXE57_RS10250	1995708..1996349	-	642	WP_000571192.1	ABC transporter ATP-binding protein	-
DXE57_RS10255	1996346..1996666	-	321	WP_000668623.1	YxeA family protein	-
DXE57_RS10260	1996669..1998633	-	1965	WP_000870811.1	bacteriocin-associated integral membrane family protein	-
DXE57_RS10265	1998677..1998961	-	285	WP_000790905.1	lactococcin 972 family bacteriocin	-
-	1999506..1999543	+	38	-	-	Antitoxin
DXE57_RS10270	1999596..1999703	-	108	WP_000623369.1	putative holin-like toxin	Toxin
DXE57_RS10275	1999973..2000575	-	603	WP_001033867.1	CPBP family intramembrane metalloprotease	-
DXE57_RS10280	2000590..2000766	-	177	WP_000214898.1	YkvS family protein	-
DXE57_RS10285	2000965..2001951	+	987	WP_000668814.1	lipoate--protein ligase	-
DXE57_RS10290	2002032..2002250	-	219	WP_000876826.1	IDEAL domain-containing protein	-
DXE57_RS10295	2002460..2003029	+	570	WP_000287265.1	competence protein ComK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3801.69 Da
• Isoelectric Point: 10.8004

>T294323 WP_000623369.1 NZ_LT992476:c1999703-1999596 [Staphylococcus aureus]
VISIANALHLMLSFGMFIVTFIGVVVAIINLNNKK

Nucleotide

• Length: 108 bp

Antitoxin

Nucleotide

• Length: 38 bp

>AT294323 NZ_LT992476:1999506-1999543 [Staphylococcus aureus]
AACATGTCGCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Antitoxin